Pharmacological intervention for cognitive deficits and aggression in frontal lobe injury

Steven G. Sugden, Shawn J. Kile, Derald D. Farrimond, Donald M. Hilty, James A. Bourgeois

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We present a case that promotes early intervention and pharmacological treatment for the neuropsychiatrie sequelae (frontal lobe syndrome, including cognitive impairment and aggressive behavior) associated with traumatic brain injury (TBI) and delirium. The patient, who sustained significant systemic complications related to his trauma, was previously diagnosed with alcohol and drug dependence and antisocial personality disorder. These antecedent conditions and prolonged systemic complications likely played a complicating role in his course of recovery.

Original languageEnglish (US)
Pages (from-to)3-7
Number of pages5
Issue number1
StatePublished - 2006


  • Aggression
  • Amantadine
  • Donepezil
  • Frontal lobe syndrome
  • Traumatic brain injury
  • Valproate

ASJC Scopus subject areas

  • Rehabilitation
  • Clinical Neurology
  • Health Professions(all)


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