Pharmacological evidence supporting a role for galanin in cognition and affect

Craige C. Wrenn, Jacqueline Crawley

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

1. Galanin is localized in brain pathways involved in both cognition and affect. 2. Galanin has inhibitory actions on a variety of memory tasks including the Morris water maze, delayed nonmatching to position, T-maze delayed alternation, starburst maze, passive avoidance, active avoidance, and spontaneous alternation. 3. Galanin may inhibit learning and memory by inhibiting neurotransmitter release and neuronal firing rate. 4. Two signal transduction mechanisms through which galanin exerts its inhibitory actions are the inhibition of phosphatidyl inositol hydrolysis and the inhibition of adenylate cyclase. 5. Galanin released during periods of burst firing from noradrenergic locus coeruleus terminals in the ventral tegmental area (VTA) may lead to symptoms of depression through inhibition of dopaminergic VTA neurons. 6. Intraventricular galanin has anxiolytic effects in a punished drinking test. Intra-amygdala galanin has anxiogenic effects in a punished drinking test.

Original languageEnglish (US)
Pages (from-to)283-299
Number of pages17
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume25
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Acetylcholine
  • Alzheimer's
  • Anxiety
  • Depression
  • Galanin
  • Glutamate
  • Learning
  • Memor y
  • Neuropeptide
  • Rodent

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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