Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats

Gabrielle Young, Geof W. Smith, Teresa L. Leavens, Scott E. Wetzlich, Ronald E. Baynes, Sharon E. Mason, Jim E. Riviere, Lisa A Tell

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25 Scopus citations

Abstract

Tulathromycin is a triamilide antibiotic that maintains therapeutic concentrations for an extended period of time. The drug is approved for the treatment of respiratory disease in cattle and swine and is occasionally used in goats. To investigate the pharmacokinetics of tulathromycin in meat goats, 10 healthy Boer goats were administered a single 2.5mg/kg subcutaneous dose of tulathromycin. Plasma concentrations were measured by ultra-high pressure liquid chromatography tandem mass spectrometry (UPLC-MS/MS) detection. Plasma maximal drug concentration (Cmax) was 633±300ng/ml (0.40±0.26h post-subcutaneous injection). The half-life of tulathromycin in goats was 110±19.9h. Tulathromycin was rapidly absorbed and distributed widely after subcutaneous injection 33±6 L/kg. The mean AUC of the group was 12,500±2020hng/mL for plasma. In this study, it was determined that the pharmacokinetics of tulathromycin after a single 2.5mg/kg SC injection in goats were very similar to what has been previously reported in cattle.

Original languageEnglish (US)
Pages (from-to)477-479
Number of pages3
JournalResearch in Veterinary Science
Volume90
Issue number3
DOIs
StatePublished - Jun 2011

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Keywords

  • Antibiotics
  • Goats
  • Pharmacokinetics
  • Respiratory disease
  • Tulathromycin

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Young, G., Smith, G. W., Leavens, T. L., Wetzlich, S. E., Baynes, R. E., Mason, S. E., Riviere, J. E., & Tell, L. A. (2011). Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats. Research in Veterinary Science, 90(3), 477-479. https://doi.org/10.1016/j.rvsc.2010.06.025