Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction

Jessica M. Hummel, Erin P. Madeen, Lisbeth K. Siddens, Sandra L. Uesugi, Tammie McQuistan, Kim A. Anderson, Ken W Turteltaub, Ted J. Ognibene, Graham Bench, Sharon K. Krueger, Stuart Harris, Jordan Smith, Susan C. Tilton, William M. Baird, David E. Williams

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is a known human carcinogen. In non-smoking adults greater than 95% of BaP exposure is through diet. The carcinogenicity of BaP is utilized by the U.S. EPA to assess relative potency of complex PAH mixtures. PAH relative potency factors (RPFs, BaP = 1) are determined from high dose animal data. We employed accelerator mass spectrometry (AMS) to determine pharmacokinetics of [14C]-BaP in humans following dosing with 46 ng (an order of magnitude lower than human dietary daily exposure and million-fold lower than animal cancer models). To assess the impact of co-administration of food with a complex PAH mixture, humans were dosed with 46 ng of [14C]-BaP with or without smoked salmon. Subjects were asked to avoid high BaP-containing diets and a 3-day dietary questionnaire given to assess dietary exposure prior to dosing and three days post-dosing with [14C]-BaP. Co-administration of smoked salmon, containing a complex mixture of PAHs with an RPF of 460 ng BaPeq, reduced and delayed absorption. Administration of canned commercial salmon, containing very low amounts of PAHs, showed the impacts on pharmacokinetics were not due to high amounts of PAHs but rather a food matrix effect.

Original languageEnglish (US)
Pages (from-to)136-147
Number of pages12
JournalFood and Chemical Toxicology
Volume115
DOIs
StatePublished - May 1 2018
Externally publishedYes

Fingerprint

smoked salmon
dietary restriction
Pharmacokinetics
Salmon
Benzo(a)pyrene
pharmacokinetics
anthropogenic activities
Polycyclic Aromatic Hydrocarbons
polycyclic aromatic hydrocarbons
Polycyclic aromatic hydrocarbons
Nutrition
Animals
Diet
benzo(a)pyrene
Food
carcinogenicity
United States Environmental Protection Agency
dietary exposure
food matrix
carcinogens

Keywords

  • Accelerator mass spectrometry
  • Benzo[a]pyrene
  • Dietary polycyclic aromatic hydrocarbons
  • Pharmacokinetics

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Hummel, J. M., Madeen, E. P., Siddens, L. K., Uesugi, S. L., McQuistan, T., Anderson, K. A., ... Williams, D. E. (2018). Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food and Chemical Toxicology, 115, 136-147. https://doi.org/10.1016/j.fct.2018.03.003

Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans : Impact of Co-Administration of smoked salmon and BaP dietary restriction. / Hummel, Jessica M.; Madeen, Erin P.; Siddens, Lisbeth K.; Uesugi, Sandra L.; McQuistan, Tammie; Anderson, Kim A.; Turteltaub, Ken W; Ognibene, Ted J.; Bench, Graham; Krueger, Sharon K.; Harris, Stuart; Smith, Jordan; Tilton, Susan C.; Baird, William M.; Williams, David E.

In: Food and Chemical Toxicology, Vol. 115, 01.05.2018, p. 136-147.

Research output: Contribution to journalArticle

Hummel, JM, Madeen, EP, Siddens, LK, Uesugi, SL, McQuistan, T, Anderson, KA, Turteltaub, KW, Ognibene, TJ, Bench, G, Krueger, SK, Harris, S, Smith, J, Tilton, SC, Baird, WM & Williams, DE 2018, 'Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction', Food and Chemical Toxicology, vol. 115, pp. 136-147. https://doi.org/10.1016/j.fct.2018.03.003
Hummel, Jessica M. ; Madeen, Erin P. ; Siddens, Lisbeth K. ; Uesugi, Sandra L. ; McQuistan, Tammie ; Anderson, Kim A. ; Turteltaub, Ken W ; Ognibene, Ted J. ; Bench, Graham ; Krueger, Sharon K. ; Harris, Stuart ; Smith, Jordan ; Tilton, Susan C. ; Baird, William M. ; Williams, David E. / Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans : Impact of Co-Administration of smoked salmon and BaP dietary restriction. In: Food and Chemical Toxicology. 2018 ; Vol. 115. pp. 136-147.
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AU - Hummel, Jessica M.

AU - Madeen, Erin P.

AU - Siddens, Lisbeth K.

AU - Uesugi, Sandra L.

AU - McQuistan, Tammie

AU - Anderson, Kim A.

AU - Turteltaub, Ken W

AU - Ognibene, Ted J.

AU - Bench, Graham

AU - Krueger, Sharon K.

AU - Harris, Stuart

AU - Smith, Jordan

AU - Tilton, Susan C.

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AU - Williams, David E.

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