Abstract
Single‐dose oral administration of a commercial polychlorinated biphenyl product containing 54% chlorine provided data with which to plot the time course of total polychlorinated biphenyl and individual components in the blood of swine and sheep. Pharmacokinetic parameters describing absorption from the gut and elimination from a two‐compartment body system were determined for the components in swine and sheep. The absorption half‐time for total polychlorinated biphenyl in swine was 1.13 hr while that for sheep was 3.83 hr. The half‐time for disposition of total polychlorinated biphenyl from the central compartment was 4.4 hr in swine and 7.7 hr in sheep; the apparent biological half‐life was 62.4 hr in swine and 78.8 hr in sheep. Individual components varied significantly from each other and from total polychlorinated biphenyl in all parameters.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1294-1299 |
| Number of pages | 6 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 64 |
| Issue number | 8 |
| DOIs | |
| State | Published - Jan 1 1975 |
| Externally published | Yes |
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Keywords
- Pharmacokinetics—polychlorinated biphenyls in swine and sheep after single oral dose
- Polychlorinated biphenyl components—pharmacokinetics in swine and sheep after single oral dose
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Pharmacokinetics of polychlorinated biphenyl components in swine and sheep after a single oral dose. / Borchard, R. E.; Welborn, M. E.; Wiekhorst, W. B.; Wilson, Dennis W; Hansen, L. G.
In: Journal of Pharmaceutical Sciences, Vol. 64, No. 8, 01.01.1975, p. 1294-1299.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics of polychlorinated biphenyl components in swine and sheep after a single oral dose
AU - Borchard, R. E.
AU - Welborn, M. E.
AU - Wiekhorst, W. B.
AU - Wilson, Dennis W
AU - Hansen, L. G.
PY - 1975/1/1
Y1 - 1975/1/1
N2 - Single‐dose oral administration of a commercial polychlorinated biphenyl product containing 54% chlorine provided data with which to plot the time course of total polychlorinated biphenyl and individual components in the blood of swine and sheep. Pharmacokinetic parameters describing absorption from the gut and elimination from a two‐compartment body system were determined for the components in swine and sheep. The absorption half‐time for total polychlorinated biphenyl in swine was 1.13 hr while that for sheep was 3.83 hr. The half‐time for disposition of total polychlorinated biphenyl from the central compartment was 4.4 hr in swine and 7.7 hr in sheep; the apparent biological half‐life was 62.4 hr in swine and 78.8 hr in sheep. Individual components varied significantly from each other and from total polychlorinated biphenyl in all parameters.
AB - Single‐dose oral administration of a commercial polychlorinated biphenyl product containing 54% chlorine provided data with which to plot the time course of total polychlorinated biphenyl and individual components in the blood of swine and sheep. Pharmacokinetic parameters describing absorption from the gut and elimination from a two‐compartment body system were determined for the components in swine and sheep. The absorption half‐time for total polychlorinated biphenyl in swine was 1.13 hr while that for sheep was 3.83 hr. The half‐time for disposition of total polychlorinated biphenyl from the central compartment was 4.4 hr in swine and 7.7 hr in sheep; the apparent biological half‐life was 62.4 hr in swine and 78.8 hr in sheep. Individual components varied significantly from each other and from total polychlorinated biphenyl in all parameters.
KW - Pharmacokinetics—polychlorinated biphenyls in swine and sheep after single oral dose
KW - Polychlorinated biphenyl components—pharmacokinetics in swine and sheep after single oral dose
UR - http://www.scopus.com/inward/record.url?scp=0016685714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016685714&partnerID=8YFLogxK
U2 - 10.1002/jps.2600640807
DO - 10.1002/jps.2600640807
M3 - Article
C2 - 807710
AN - SCOPUS:0016685714
VL - 64
SP - 1294
EP - 1299
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 8
ER -