Pharmacokinetics of piperacillin after intramuscular injection in red-tailed hawks (buteo jamaicensis) and great horned owls (bubo virginianus)

P. K. Robbins, Lisa A Tell, Martha L. Needham, Arthur L. Craigmill

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This study characterized and compared the pharmacokinetics of piperacillin after single 100 mg/kg i.m. injections in nine red-tailed hawks (Buteo jamaicensis) and five great horned owls (Bubo virginianus) over 48 hr by a modified agar well diffusion microbial inhibition assay. The mean maximum plasma piperacillin concentrations were 204 μg/ml and 221 μg/ml for the hawks and owls, respectively, and times of maximum concentrations were 15 min and 30 min, respectively. The calculated mean terminal elimination half-lives were 77 min in the hawks and 118 min in the owls. Area-under-the-curve values were 218 ± 52 μg·hr/ml in the hawks and 444 ± 104 μg·hr/ml in the owls. On the basis of the most common minimal inhibitory concentration (90%) for various bacterial isolates from clinical samples of 8 μg/ml, analysis of the data suggests that the maximum dosing interval for piperacillin at 100 mg/kg in medium sized raptors should be 4-6 hr.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalJournal of Zoo and Wildlife Medicine
Volume31
Issue number1
StatePublished - 2000

Keywords

  • Bubo virginianus
  • Buteo jamaicensis
  • Great horned owl
  • Pharmacokinetics
  • Piperacillin
  • Red-tailed hawk

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Environmental Science(all)
  • veterinary(all)

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