Pharmacokinetics of meloxicam after intravenous, intramuscular, and oral administration of a single dose to Hispaniolan amazon parrots (Amazona ventralis)

Christine M. Molter, Michael H. Court, Gretchen A. Cole, David J. Gagnon, Suwagmani Hazarika, Joanne R Paul-Murphy

Research output: Contribution to journalArticle

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Abstract

Objective-To compare pharmacokinetics after IV, IM, and oral administration of a single dose of meloxicam to Hispaniolan Amazon parrots (Amazona ventralis). Animals-11 healthy parrots. Procedures-Cohorts of 8 of the 11 birds comprised 3 experimental groups for a crossover study. Pharmacokinetics were determined from plasma concentrations measured via highperformance liquid chromatography after IV, IM, and oral administration of meloxicam at a dose of 1 mg/kg. Results-Initial mean ± SD plasma concentration of 17.3 ± 9.0 μg/mL was measured 5 minutes after IV administration, whereas peak mean concentration was 9.3 ± 1.8 μg/mL 15 minutes after IM administration. At 12 hours after administration, mean plasma concentrations for IV (3.7 ± 2.5 μg/mL) and IM (3.5 ± 2.2 μg/mL) administration were similar. Peak mean plasma concentration (3.5 ± 1.2 μg/mL) was detected 6 hours after oral administration. Absolute systemic bioavailability of meloxicam after IM administration was 100% but was lower after oral administration (range, 49% to 75%). Elimination half-lives after IV, IM, and oral administration were similar (15.9 ± 4.4 hours, 15.1 ± 7.7 hours, and 15.8 ± 8.6 hours, respectively). Conclusions and Clinical Relevance-Pharmacokinetic data may provide useful information for use of meloxicam in Hispaniolan Amazon parrots. A mean plasma concentration of 3.5 μg/mL would be expected to provide analgesia in Hispaniolan Amazon parrots; however, individual variation may result in some birds having low plasma meloxicam concentrations after IV, IM, or oral administration. After oral administration, meloxicam concentration slowly reached the target plasma concentration, but that concentration was not sustained in most birds.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume74
Issue number3
DOIs
StatePublished - Mar 2013

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meloxicam
Amazona
parrots
intramuscular injection
intravenous injection
Intravenous Administration
oral administration
pharmacokinetics
Oral Administration
Pharmacokinetics
dosage
Birds
birds
Parrots
analgesia
Liquid Chromatography
Analgesia
Cross-Over Studies
liquid chromatography
Biological Availability

ASJC Scopus subject areas

  • veterinary(all)

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Pharmacokinetics of meloxicam after intravenous, intramuscular, and oral administration of a single dose to Hispaniolan amazon parrots (Amazona ventralis). / Molter, Christine M.; Court, Michael H.; Cole, Gretchen A.; Gagnon, David J.; Hazarika, Suwagmani; Paul-Murphy, Joanne R.

In: American Journal of Veterinary Research, Vol. 74, No. 3, 03.2013, p. 375-380.

Research output: Contribution to journalArticle

Molter, Christine M. ; Court, Michael H. ; Cole, Gretchen A. ; Gagnon, David J. ; Hazarika, Suwagmani ; Paul-Murphy, Joanne R. / Pharmacokinetics of meloxicam after intravenous, intramuscular, and oral administration of a single dose to Hispaniolan amazon parrots (Amazona ventralis). In: American Journal of Veterinary Research. 2013 ; Vol. 74, No. 3. pp. 375-380.
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abstract = "Objective-To compare pharmacokinetics after IV, IM, and oral administration of a single dose of meloxicam to Hispaniolan Amazon parrots (Amazona ventralis). Animals-11 healthy parrots. Procedures-Cohorts of 8 of the 11 birds comprised 3 experimental groups for a crossover study. Pharmacokinetics were determined from plasma concentrations measured via highperformance liquid chromatography after IV, IM, and oral administration of meloxicam at a dose of 1 mg/kg. Results-Initial mean ± SD plasma concentration of 17.3 ± 9.0 μg/mL was measured 5 minutes after IV administration, whereas peak mean concentration was 9.3 ± 1.8 μg/mL 15 minutes after IM administration. At 12 hours after administration, mean plasma concentrations for IV (3.7 ± 2.5 μg/mL) and IM (3.5 ± 2.2 μg/mL) administration were similar. Peak mean plasma concentration (3.5 ± 1.2 μg/mL) was detected 6 hours after oral administration. Absolute systemic bioavailability of meloxicam after IM administration was 100{\%} but was lower after oral administration (range, 49{\%} to 75{\%}). Elimination half-lives after IV, IM, and oral administration were similar (15.9 ± 4.4 hours, 15.1 ± 7.7 hours, and 15.8 ± 8.6 hours, respectively). Conclusions and Clinical Relevance-Pharmacokinetic data may provide useful information for use of meloxicam in Hispaniolan Amazon parrots. A mean plasma concentration of 3.5 μg/mL would be expected to provide analgesia in Hispaniolan Amazon parrots; however, individual variation may result in some birds having low plasma meloxicam concentrations after IV, IM, or oral administration. After oral administration, meloxicam concentration slowly reached the target plasma concentration, but that concentration was not sustained in most birds.",
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AU - Hazarika, Suwagmani

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AB - Objective-To compare pharmacokinetics after IV, IM, and oral administration of a single dose of meloxicam to Hispaniolan Amazon parrots (Amazona ventralis). Animals-11 healthy parrots. Procedures-Cohorts of 8 of the 11 birds comprised 3 experimental groups for a crossover study. Pharmacokinetics were determined from plasma concentrations measured via highperformance liquid chromatography after IV, IM, and oral administration of meloxicam at a dose of 1 mg/kg. Results-Initial mean ± SD plasma concentration of 17.3 ± 9.0 μg/mL was measured 5 minutes after IV administration, whereas peak mean concentration was 9.3 ± 1.8 μg/mL 15 minutes after IM administration. At 12 hours after administration, mean plasma concentrations for IV (3.7 ± 2.5 μg/mL) and IM (3.5 ± 2.2 μg/mL) administration were similar. Peak mean plasma concentration (3.5 ± 1.2 μg/mL) was detected 6 hours after oral administration. Absolute systemic bioavailability of meloxicam after IM administration was 100% but was lower after oral administration (range, 49% to 75%). Elimination half-lives after IV, IM, and oral administration were similar (15.9 ± 4.4 hours, 15.1 ± 7.7 hours, and 15.8 ± 8.6 hours, respectively). Conclusions and Clinical Relevance-Pharmacokinetic data may provide useful information for use of meloxicam in Hispaniolan Amazon parrots. A mean plasma concentration of 3.5 μg/mL would be expected to provide analgesia in Hispaniolan Amazon parrots; however, individual variation may result in some birds having low plasma meloxicam concentrations after IV, IM, or oral administration. After oral administration, meloxicam concentration slowly reached the target plasma concentration, but that concentration was not sustained in most birds.

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