Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses

Heather K Knych, Rick Arthur, Stacy Steinmetz, Dan S. McKemie

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ketoprofen (KTP) is currently only available as an injectable formulation for intravenous administration to horses. The primary goal of the study reported here was to characterize the pharmacokinetics of KTP, including determination of bioavailability following oral administration of the currently available injectable formulation as well as a paste formulation. KTP was administered intravenously and orally, and blood and urine samples were collected at various time points up to 96 h. KTP enantiomer concentrations were determined using LC-MS/MS, and pharmacokinetic analyses were performed. Mean ± standard error values for systemic clearance, steady state volume of distribution and terminal elimination half-life were 0.345 ± 0.033 [R(-) KTP] and 0.167 ± 0.016 [S(+) KTP] L/kg/h, 0.344 ± 0.044 [R(-) KTP] and 0.298 ± 0.025 [S(+) KTP] L/kg, and 2.49 ± 0.077 [R(-) KTP] and 2.86 ± 0.102 [S(+) KTP] h, respectively. Oral bioavailability was calculated as 69.5 ± 10.3% and 88.2 ± 15.9% for R(-) KTP and S(+) KTP, respectively, following administration of the injectable formulation and 53.0 ± 6.0 and 53.0 ± 16.0% for the R(-) KTP and S(+) KTP, respectively, following administration of KTP paste.

Original languageEnglish (US)
Pages (from-to)196-198
Number of pages3
JournalVeterinary Journal
Volume207
DOIs
StatePublished - Jan 1 2016

Fingerprint

ketoprofen
Ketoprofen
enantiomers
intravenous injection
Intravenous Administration
oral administration
pharmacokinetics
Horses
Oral Administration
Pharmacokinetics
horses
Ointments
Biological Availability
Injections
bioavailability

Keywords

  • Bioavailability
  • Horse
  • Ketoprofen
  • NSAID
  • Pharmacokinetics

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses. / Knych, Heather K; Arthur, Rick; Steinmetz, Stacy; McKemie, Dan S.

In: Veterinary Journal, Vol. 207, 01.01.2016, p. 196-198.

Research output: Contribution to journalArticle

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abstract = "Ketoprofen (KTP) is currently only available as an injectable formulation for intravenous administration to horses. The primary goal of the study reported here was to characterize the pharmacokinetics of KTP, including determination of bioavailability following oral administration of the currently available injectable formulation as well as a paste formulation. KTP was administered intravenously and orally, and blood and urine samples were collected at various time points up to 96 h. KTP enantiomer concentrations were determined using LC-MS/MS, and pharmacokinetic analyses were performed. Mean ± standard error values for systemic clearance, steady state volume of distribution and terminal elimination half-life were 0.345 ± 0.033 [R(-) KTP] and 0.167 ± 0.016 [S(+) KTP] L/kg/h, 0.344 ± 0.044 [R(-) KTP] and 0.298 ± 0.025 [S(+) KTP] L/kg, and 2.49 ± 0.077 [R(-) KTP] and 2.86 ± 0.102 [S(+) KTP] h, respectively. Oral bioavailability was calculated as 69.5 ± 10.3{\%} and 88.2 ± 15.9{\%} for R(-) KTP and S(+) KTP, respectively, following administration of the injectable formulation and 53.0 ± 6.0 and 53.0 ± 16.0{\%} for the R(-) KTP and S(+) KTP, respectively, following administration of KTP paste.",
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