Abstract
Ketoprofen (KTP) is currently only available as an injectable formulation for intravenous administration to horses. The primary goal of the study reported here was to characterize the pharmacokinetics of KTP, including determination of bioavailability following oral administration of the currently available injectable formulation as well as a paste formulation. KTP was administered intravenously and orally, and blood and urine samples were collected at various time points up to 96 h. KTP enantiomer concentrations were determined using LC-MS/MS, and pharmacokinetic analyses were performed. Mean ± standard error values for systemic clearance, steady state volume of distribution and terminal elimination half-life were 0.345 ± 0.033 [R(-) KTP] and 0.167 ± 0.016 [S(+) KTP] L/kg/h, 0.344 ± 0.044 [R(-) KTP] and 0.298 ± 0.025 [S(+) KTP] L/kg, and 2.49 ± 0.077 [R(-) KTP] and 2.86 ± 0.102 [S(+) KTP] h, respectively. Oral bioavailability was calculated as 69.5 ± 10.3% and 88.2 ± 15.9% for R(-) KTP and S(+) KTP, respectively, following administration of the injectable formulation and 53.0 ± 6.0 and 53.0 ± 16.0% for the R(-) KTP and S(+) KTP, respectively, following administration of KTP paste.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 196-198 |
| Number of pages | 3 |
| Journal | Veterinary Journal |
| Volume | 207 |
| DOIs | |
| State | Published - Jan 1 2016 |
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Keywords
- Bioavailability
- Horse
- Ketoprofen
- NSAID
- Pharmacokinetics
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses. / Knych, Heather K; Arthur, Rick; Steinmetz, Stacy; McKemie, Dan S.
In: Veterinary Journal, Vol. 207, 01.01.2016, p. 196-198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses
AU - Knych, Heather K
AU - Arthur, Rick
AU - Steinmetz, Stacy
AU - McKemie, Dan S.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Ketoprofen (KTP) is currently only available as an injectable formulation for intravenous administration to horses. The primary goal of the study reported here was to characterize the pharmacokinetics of KTP, including determination of bioavailability following oral administration of the currently available injectable formulation as well as a paste formulation. KTP was administered intravenously and orally, and blood and urine samples were collected at various time points up to 96 h. KTP enantiomer concentrations were determined using LC-MS/MS, and pharmacokinetic analyses were performed. Mean ± standard error values for systemic clearance, steady state volume of distribution and terminal elimination half-life were 0.345 ± 0.033 [R(-) KTP] and 0.167 ± 0.016 [S(+) KTP] L/kg/h, 0.344 ± 0.044 [R(-) KTP] and 0.298 ± 0.025 [S(+) KTP] L/kg, and 2.49 ± 0.077 [R(-) KTP] and 2.86 ± 0.102 [S(+) KTP] h, respectively. Oral bioavailability was calculated as 69.5 ± 10.3% and 88.2 ± 15.9% for R(-) KTP and S(+) KTP, respectively, following administration of the injectable formulation and 53.0 ± 6.0 and 53.0 ± 16.0% for the R(-) KTP and S(+) KTP, respectively, following administration of KTP paste.
AB - Ketoprofen (KTP) is currently only available as an injectable formulation for intravenous administration to horses. The primary goal of the study reported here was to characterize the pharmacokinetics of KTP, including determination of bioavailability following oral administration of the currently available injectable formulation as well as a paste formulation. KTP was administered intravenously and orally, and blood and urine samples were collected at various time points up to 96 h. KTP enantiomer concentrations were determined using LC-MS/MS, and pharmacokinetic analyses were performed. Mean ± standard error values for systemic clearance, steady state volume of distribution and terminal elimination half-life were 0.345 ± 0.033 [R(-) KTP] and 0.167 ± 0.016 [S(+) KTP] L/kg/h, 0.344 ± 0.044 [R(-) KTP] and 0.298 ± 0.025 [S(+) KTP] L/kg, and 2.49 ± 0.077 [R(-) KTP] and 2.86 ± 0.102 [S(+) KTP] h, respectively. Oral bioavailability was calculated as 69.5 ± 10.3% and 88.2 ± 15.9% for R(-) KTP and S(+) KTP, respectively, following administration of the injectable formulation and 53.0 ± 6.0 and 53.0 ± 16.0% for the R(-) KTP and S(+) KTP, respectively, following administration of KTP paste.
KW - Bioavailability
KW - Horse
KW - Ketoprofen
KW - NSAID
KW - Pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=84952884937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952884937&partnerID=8YFLogxK
U2 - 10.1016/j.tvjl.2015.09.018
DO - 10.1016/j.tvjl.2015.09.018
M3 - Article
C2 - 27152386
AN - SCOPUS:84952884937
VL - 207
SP - 196
EP - 198
JO - Veterinary Journal
JF - Veterinary Journal
SN - 1090-0233
ER -