Pharmacokinetics of intravenous administered two different high doses of ascorbic acid in healthy beagle dogs

Seula Lim, Ye In Oh, Jong Woo Jeong, Kun Ho Song, Tae Sung Koo, Kyoung Won Seo

Research output: Contribution to journalArticle

Abstract

Objective: We performed a randomized two-way crossover study to evaluate the pharmacokinetic profiles of two high-dose ascorbic acid (AA) after IV infusion in healthy beagle dogs. Materials and Methods: The dogs were administered IV AA at two doses of 1.5 and 3 gm/kg for 4 h, and the AA concentration in plasma and urine pH was measured before and after administration. Results: The plasma concentrations of AA in both groups peaked 3 h after administration. Among the two groups, the urine pH was not significantly different (p = 0.1299-0.7944). High-dose IV AA did not induce serious adverse events in dogs. Conclusion: The results of this study suggest that the high dose of AA which reaches the therapeutic dose for cancer and supports the safety of high-dose IV AA in dogs.

Original languageEnglish (US)
Pages (from-to)481-485
Number of pages5
JournalJournal of Advanced Veterinary and Animal Research
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2019
Externally publishedYes

Keywords

  • Ascorbic acid
  • Dog
  • Pharmacokinetics

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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