Pharmacokinetics of indium-111 BLEDTA in man

D. J. Sartoris, D. A. Goodwin, C. F. Meares, L. H. DeRiemer, L. F. Fajardo

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

111In-BLEDTA is a bleomycin-containing radiopharmaceutical that has proven useful as a tumor imaging agent. Whole blood distribution and pharmacokinetic parameters were studied in nine cancer patients, and the results compared with previously reported studies using 57Co-bleomycin. In eight patients studied by bolus intravenous injection, 111In-BLEDTA had a beta half-life (t( 1/2 β)) of 1.3 hours, a terminal-phase half-life (t( 1/2 )) of 11.7 hours, a volume of distribution (V(dγ)) of 57.5 L/m2, a total body clearance rate (C(1b2)) of 52.8 ml/min/m2, a renal clearance rate (C1(r)) of 23.3 ml/min/m2, and a 24-hour urinary excretion of 38.1% total administered dose. 111In-BLEDTA and 57Co-bleomycin have similar C1(bs) but differing V(ds). Polymorphonuclear cell uptake of 111In-BLEDTA may explain its shorter t( 1/2 β) and t( 1/2 ), as well as its lower C1(r) and 24-hour urinary excretion. While the biologic characteristics of 111In-BLEDTA contribute to a greater background activity than is observed in scans with 57Co-bleomycin, its superior physical properties render it clinically more desirable as a tumor-imaging radiopharmaceutical.

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
JournalInvestigative Radiology
Volume19
Issue number3
StatePublished - 1984

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Sartoris, D. J., Goodwin, D. A., Meares, C. F., DeRiemer, L. H., & Fajardo, L. F. (1984). Pharmacokinetics of indium-111 BLEDTA in man. Investigative Radiology, 19(3), 221-227.