Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses

J. A. Orsini, P. J. Moate, R. C. Boston, T. Norman, J. Engiles, C. E. Benson, Robert H Poppenga

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

In two studies, six healthy adult horses were given imipenem-cilastatin by slow intravenous (i.v.) infusion at an imipenem dosage of 10 mg/kg (study 1) and 20 mg/kg (study 2). The same horses were used in each dosage schedule, with a 2-week washout period between studies. In each dosage group, serial blood and synovial fluid samples were collected for 6 h after completion of the infusion. HPLC was used to determine the imipenem concentration in all samples. Imipenem was well tolerated by all horses at both dosages; no adverse effects were noted during the study period or during the 24-hour postinfusion observation period. The pharmacokinetic profiles of imipenem in the plasma and synovial fluid indicate that an imipenem dosage of 10-20 mg/kg by slow i.v. infusion q6h (every 6 h) is appropriate for most susceptible pathogens.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume28
Issue number4
DOIs
StatePublished - Aug 2005
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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