Abstract
In two studies, six healthy adult horses were given imipenem-cilastatin by slow intravenous (i.v.) infusion at an imipenem dosage of 10 mg/kg (study 1) and 20 mg/kg (study 2). The same horses were used in each dosage schedule, with a 2-week washout period between studies. In each dosage group, serial blood and synovial fluid samples were collected for 6 h after completion of the infusion. HPLC was used to determine the imipenem concentration in all samples. Imipenem was well tolerated by all horses at both dosages; no adverse effects were noted during the study period or during the 24-hour postinfusion observation period. The pharmacokinetic profiles of imipenem in the plasma and synovial fluid indicate that an imipenem dosage of 10-20 mg/kg by slow i.v. infusion q6h (every 6 h) is appropriate for most susceptible pathogens.
Original language | English (US) |
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Pages (from-to) | 355-361 |
Number of pages | 7 |
Journal | Journal of Veterinary Pharmacology and Therapeutics |
Volume | 28 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- veterinary(all)