Abstract
In two studies, six healthy adult horses were given imipenem-cilastatin by slow intravenous (i.v.) infusion at an imipenem dosage of 10 mg/kg (study 1) and 20 mg/kg (study 2). The same horses were used in each dosage schedule, with a 2-week washout period between studies. In each dosage group, serial blood and synovial fluid samples were collected for 6 h after completion of the infusion. HPLC was used to determine the imipenem concentration in all samples. Imipenem was well tolerated by all horses at both dosages; no adverse effects were noted during the study period or during the 24-hour postinfusion observation period. The pharmacokinetic profiles of imipenem in the plasma and synovial fluid indicate that an imipenem dosage of 10-20 mg/kg by slow i.v. infusion q6h (every 6 h) is appropriate for most susceptible pathogens.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 355-361 |
| Number of pages | 7 |
| Journal | Journal of Veterinary Pharmacology and Therapeutics |
| Volume | 28 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2005 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- veterinary(all)
Cite this
Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses. / Orsini, J. A.; Moate, P. J.; Boston, R. C.; Norman, T.; Engiles, J.; Benson, C. E.; Poppenga, Robert H.
In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 28, No. 4, 08.2005, p. 355-361.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses
AU - Orsini, J. A.
AU - Moate, P. J.
AU - Boston, R. C.
AU - Norman, T.
AU - Engiles, J.
AU - Benson, C. E.
AU - Poppenga, Robert H
PY - 2005/8
Y1 - 2005/8
N2 - In two studies, six healthy adult horses were given imipenem-cilastatin by slow intravenous (i.v.) infusion at an imipenem dosage of 10 mg/kg (study 1) and 20 mg/kg (study 2). The same horses were used in each dosage schedule, with a 2-week washout period between studies. In each dosage group, serial blood and synovial fluid samples were collected for 6 h after completion of the infusion. HPLC was used to determine the imipenem concentration in all samples. Imipenem was well tolerated by all horses at both dosages; no adverse effects were noted during the study period or during the 24-hour postinfusion observation period. The pharmacokinetic profiles of imipenem in the plasma and synovial fluid indicate that an imipenem dosage of 10-20 mg/kg by slow i.v. infusion q6h (every 6 h) is appropriate for most susceptible pathogens.
AB - In two studies, six healthy adult horses were given imipenem-cilastatin by slow intravenous (i.v.) infusion at an imipenem dosage of 10 mg/kg (study 1) and 20 mg/kg (study 2). The same horses were used in each dosage schedule, with a 2-week washout period between studies. In each dosage group, serial blood and synovial fluid samples were collected for 6 h after completion of the infusion. HPLC was used to determine the imipenem concentration in all samples. Imipenem was well tolerated by all horses at both dosages; no adverse effects were noted during the study period or during the 24-hour postinfusion observation period. The pharmacokinetic profiles of imipenem in the plasma and synovial fluid indicate that an imipenem dosage of 10-20 mg/kg by slow i.v. infusion q6h (every 6 h) is appropriate for most susceptible pathogens.
UR - http://www.scopus.com/inward/record.url?scp=23244452745&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23244452745&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2885.2005.00667.x
DO - 10.1111/j.1365-2885.2005.00667.x
M3 - Article
C2 - 16050815
AN - SCOPUS:23244452745
VL - 28
SP - 355
EP - 361
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
SN - 0140-7783
IS - 4
ER -