Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses

J. A. Orsini, P. J. Moate, R. C. Boston, T. Norman, J. Engiles, C. E. Benson, Robert H Poppenga

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In two studies, six healthy adult horses were given imipenem-cilastatin by slow intravenous (i.v.) infusion at an imipenem dosage of 10 mg/kg (study 1) and 20 mg/kg (study 2). The same horses were used in each dosage schedule, with a 2-week washout period between studies. In each dosage group, serial blood and synovial fluid samples were collected for 6 h after completion of the infusion. HPLC was used to determine the imipenem concentration in all samples. Imipenem was well tolerated by all horses at both dosages; no adverse effects were noted during the study period or during the 24-hour postinfusion observation period. The pharmacokinetic profiles of imipenem in the plasma and synovial fluid indicate that an imipenem dosage of 10-20 mg/kg by slow i.v. infusion q6h (every 6 h) is appropriate for most susceptible pathogens.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume28
Issue number4
DOIs
StatePublished - Aug 2005
Externally publishedYes

Fingerprint

imipenem
Imipenem
intravenous injection
Intravenous Administration
pharmacokinetics
Horses
Pharmacokinetics
horses
Synovial Fluid
dosage
synovial fluid
Intravenous Infusions
Appointments and Schedules
High Pressure Liquid Chromatography
Observation
imipenem drug combination cilastatin
adverse effects
sampling
pathogens
blood

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses. / Orsini, J. A.; Moate, P. J.; Boston, R. C.; Norman, T.; Engiles, J.; Benson, C. E.; Poppenga, Robert H.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 28, No. 4, 08.2005, p. 355-361.

Research output: Contribution to journalArticle

Orsini, J. A. ; Moate, P. J. ; Boston, R. C. ; Norman, T. ; Engiles, J. ; Benson, C. E. ; Poppenga, Robert H. / Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses. In: Journal of Veterinary Pharmacology and Therapeutics. 2005 ; Vol. 28, No. 4. pp. 355-361.
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