Abstract
Plasma concentrations and pharmacokinetics of erythromycin and related compounds were determined after administration of erythromycin ethylsuccinate to six healthy male foals 3 to 5 months of age. Hay was withheld from the foals overnight and erythromycin ethylsuccinate (25 mg/kg of body weight) was administered intragastrically. Plasma erythromycin concentrations were determined at specific times after drug administration by high-performance liquid chromatography assay. Maximum peak plasma concentrations, time to maximum concentrations, area under plasma concentration versus time curves, elimination half-life, and mean residence time were determined from concentration versus time curves. Maximum peak concentration of erythromycin A (0.45 ± 0.27 μg/ml) after administration of erythromycin ethylsuccinate was observed at 2.38 ± 1.54 hours after treatment. Concentrations of anhydroerythromycin A were maximal at 2.2 ± 2.0 hours and reached a maximum of 2.6 ± 1.9 μg/ml. Plasma concentrations of the ester parent drug (erythromycin ethylsuccinate) were below the limit of quantitation (0.1 μg/ml) at all times except 2.5, 2.75, and 5.5 hours. Levels at those times ranged from 0.1 to 0.144 μg/ml. Erythromycin ethylsuccinate appears to be poorly absorbed after oral administration to fasted foals. Plasma concentrations of erythromycin A remained below 0.25 μg/ml (reported minimum inhibitory concentration for Rhodococcus equi) for less than 4 hours after intragastric administration of erythromycin ethylsuccinate, suggesting that the recommended dosage (25 mg/kg every 6 hours) would be suboptimal for treatment of R. equi infections.
| Original language | English (US) |
|---|---|
| Journal | Veterinary Therapeutics |
| Volume | 3 |
| Issue number | 2 |
| State | Published - 2002 |
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ASJC Scopus subject areas
- veterinary(all)
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Pharmacokinetics of erythromycin ethylsuccinate after intragastric administration to healthy foals. / Perkinson, Anna; Lakritz, Jeffrey; Wilson, William D; Marsh, Antoinette; Mihalyi, Judy.
In: Veterinary Therapeutics, Vol. 3, No. 2, 2002.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics of erythromycin ethylsuccinate after intragastric administration to healthy foals
AU - Perkinson, Anna
AU - Lakritz, Jeffrey
AU - Wilson, William D
AU - Marsh, Antoinette
AU - Mihalyi, Judy
PY - 2002
Y1 - 2002
N2 - Plasma concentrations and pharmacokinetics of erythromycin and related compounds were determined after administration of erythromycin ethylsuccinate to six healthy male foals 3 to 5 months of age. Hay was withheld from the foals overnight and erythromycin ethylsuccinate (25 mg/kg of body weight) was administered intragastrically. Plasma erythromycin concentrations were determined at specific times after drug administration by high-performance liquid chromatography assay. Maximum peak plasma concentrations, time to maximum concentrations, area under plasma concentration versus time curves, elimination half-life, and mean residence time were determined from concentration versus time curves. Maximum peak concentration of erythromycin A (0.45 ± 0.27 μg/ml) after administration of erythromycin ethylsuccinate was observed at 2.38 ± 1.54 hours after treatment. Concentrations of anhydroerythromycin A were maximal at 2.2 ± 2.0 hours and reached a maximum of 2.6 ± 1.9 μg/ml. Plasma concentrations of the ester parent drug (erythromycin ethylsuccinate) were below the limit of quantitation (0.1 μg/ml) at all times except 2.5, 2.75, and 5.5 hours. Levels at those times ranged from 0.1 to 0.144 μg/ml. Erythromycin ethylsuccinate appears to be poorly absorbed after oral administration to fasted foals. Plasma concentrations of erythromycin A remained below 0.25 μg/ml (reported minimum inhibitory concentration for Rhodococcus equi) for less than 4 hours after intragastric administration of erythromycin ethylsuccinate, suggesting that the recommended dosage (25 mg/kg every 6 hours) would be suboptimal for treatment of R. equi infections.
AB - Plasma concentrations and pharmacokinetics of erythromycin and related compounds were determined after administration of erythromycin ethylsuccinate to six healthy male foals 3 to 5 months of age. Hay was withheld from the foals overnight and erythromycin ethylsuccinate (25 mg/kg of body weight) was administered intragastrically. Plasma erythromycin concentrations were determined at specific times after drug administration by high-performance liquid chromatography assay. Maximum peak plasma concentrations, time to maximum concentrations, area under plasma concentration versus time curves, elimination half-life, and mean residence time were determined from concentration versus time curves. Maximum peak concentration of erythromycin A (0.45 ± 0.27 μg/ml) after administration of erythromycin ethylsuccinate was observed at 2.38 ± 1.54 hours after treatment. Concentrations of anhydroerythromycin A were maximal at 2.2 ± 2.0 hours and reached a maximum of 2.6 ± 1.9 μg/ml. Plasma concentrations of the ester parent drug (erythromycin ethylsuccinate) were below the limit of quantitation (0.1 μg/ml) at all times except 2.5, 2.75, and 5.5 hours. Levels at those times ranged from 0.1 to 0.144 μg/ml. Erythromycin ethylsuccinate appears to be poorly absorbed after oral administration to fasted foals. Plasma concentrations of erythromycin A remained below 0.25 μg/ml (reported minimum inhibitory concentration for Rhodococcus equi) for less than 4 hours after intragastric administration of erythromycin ethylsuccinate, suggesting that the recommended dosage (25 mg/kg every 6 hours) would be suboptimal for treatment of R. equi infections.
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M3 - Article
C2 - 19750750
AN - SCOPUS:79251470803
VL - 3
JO - Veterinary therapeutics : research in applied veterinary medicine
JF - Veterinary therapeutics : research in applied veterinary medicine
SN - 1528-3593
IS - 2
ER -