Pharmacokinetics of ceftiofur sodium in exotic and domestic avian species

Lisa A Tell, L. Harrenstien, S. Wetzlich, M. Needham, J. Nappier, G. Hoffman, J. Caputo, A. Craigmill

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The pharmacokinetics of ceftiofur sodium were determined in domestic chicks, turkey poults, adult cockatiels (Nymphicus hollandicus), and adult orange-winged Amazon parrots (Amazona amazonica) after subcutaneous (chicks and turkey poults) and intramuscular (i.m.) dosing (cockatiels and Amazon parrots). Turkey poult data were best fit to a single exponential model with disappearance half-lives (t( 1/4 )) of 8.6, 7.4 and 5.6 h after doses of 0.12, 0.24 and 0.48 mg ceftiofur free acid equivalents (CFAE)/poult, respectively. Data from chicks were best fit to a biexponential model with primary and secondary half-lives of 2.2 and 7.5, 3.7 and 6.8, and 3.8 and 5.3 h after doses of 0.04, 0.08 and 0.16 mg CFAE/chick, respectively. Cockatiel and Amazon parrot data were best fit to a biexponential model with primary and secondary half-lives of 0.28 and 2.5, and 0.93 and 7.9 h, respectively, after doses of 10 mg CFAE/kg body weight. The maximum concentration (C(max)) and area under the concentration time curve (AUC) in chicks and poults were dose- proportional. The C(max) for cockatiels was 5.2 μg/mL and for Amazon parrots was 11 μg/mL. Clearance in cockatiels and Amazon parrots were 11.3 and 3.8 mL/min/kg, respectively, and reflected the much greater AUC seen in Amazon parrots. Clearance values of ceftiofur were similar in chicks and Amazon parrots, slightly greater in turkey poults and greatest in cockatiels. These results indicate that pharmacokinetic differences must be considered when establishing dosage regimens for different avian species.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume21
Issue number1
StatePublished - 1998

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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    Tell, L. A., Harrenstien, L., Wetzlich, S., Needham, M., Nappier, J., Hoffman, G., Caputo, J., & Craigmill, A. (1998). Pharmacokinetics of ceftiofur sodium in exotic and domestic avian species. Journal of Veterinary Pharmacology and Therapeutics, 21(1), 85-91.