Pharmacokinetics of ceftiofur sodium and ceftiofur crystalline free acid in neonatal foals

T. L. Hall, Lisa A Tell, S. E. Wetzlich, J. D. Mccormick, L. W. Fowler, Nicola Pusterla

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Ceftiofur, a third generation cephalosporin, demonstrates in vitro efficacy against microorganisms isolated from septicemic neonatal foals. This pharmacokinetic study evaluated the intravenous and subcutaneous administration of ceftiofur sodium (5mg/kg body weight; n=6 per group) and subcutaneous administration of ceftiofur crystalline free acid (6.6mg/kg body weight; n=6) in healthy foals. Plasma ceftiofur- and desfuroylceftiofur-related metabolite concentrations were measured using high performance liquid chromatography following drug administration. Mean (±SD) noncompartmental pharmacokinetic parameters for i.v. and s.c. ceftiofur sodium were: AUC 0→∝ (86.4±8.5 and 91±22h·μg/mL for i.v. and s.c., respectively), terminal elimination half-life (5.82±1.00 and 5.55±0.81h for i.v. and s.c., respectively), C max(obs) (13±1.9μg/mL s.c.), T max(obs) (0.75±0.4h for s.c.). Mean (± SD) noncompartmental pharmacokinetic parameters for s.c. ceftiofur crystalline free acid were: AUC 0→∝ (139.53±22.63h·μg/mL), terminal elimination half-life (39.7±14.7), C max(obs) (2.52±0.35μg/mL) and t max(obs) (11.33±1.63h). No adverse effects attributed to drug administration were observed in any foal. Ceftiofur- and desfuroylceftiofur-related metabolites reached sufficient plasma concentrations to effectively treat common bacterial pathogens isolated from septicemic foals.

Original languageEnglish (US)
Pages (from-to)403-409
Number of pages7
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume34
Issue number4
DOIs
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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