Abstract
Six adult male alpacas received one subcutaneous administration of ceftiofur crystalline free acid (CCFA) at a dosage of 6.6mg/kg. After a washout period, the same alpacas received three subcutaneous doses of 6.6mg/kg CCFA at 5-day intervals. Blood samples collected from the jugular vein before and at multiple time points after each CCFA administration were assayed for ceftiofur- and desfuroylceftiofur-related metabolite concentrations using high-performance liquid chromatography. Pharmacokinetic disposition of CCFA was analyzed by a noncompartmental approach. Mean pharmacokinetic parameters (±SD) following single-dose administration of CCFA were Cmax (2.7±0.9μg/mL); Tmax (36±0h); area under the curve AUC0→∞ (199.2±42.1μg·h/mL); terminal phase rate constant λz (0.02±0.003/h); and terminal phase rate constant half-life t1/2λz (44.7h; harmonic). Mean terminal pharmacokinetic parameters (±SD) following three administrations of CCFA were Cmax (2.0±0.4μg/mL); Tmax (17.3±16.3h); AUC0→∞ (216.8±84.5μg·h/mL); λz (0.01±0.003/h); and t1/2λz (65.9h; harmonic). The terminal phase rate constant and the Tmax were significantly different between single and multiple administrations. Local reactions were noted in two alpacas following multiple CCFA administrations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 122-129 |
| Number of pages | 8 |
| Journal | Journal of Veterinary Pharmacology and Therapeutics |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2013 |
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ASJC Scopus subject areas
- Pharmacology
- veterinary(all)
Cite this
Pharmacokinetics of ceftiofur crystalline free acid after single and multiple subcutaneous administrations in healthy alpacas (Vicugna pacos). / Dechant, Julie E; Rowe, Joan D; Byrne, Barbara A; Wetzlich, S. E.; Kieu, H. T.; Tell, Lisa A.
In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 36, No. 2, 04.2013, p. 122-129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics of ceftiofur crystalline free acid after single and multiple subcutaneous administrations in healthy alpacas (Vicugna pacos)
AU - Dechant, Julie E
AU - Rowe, Joan D
AU - Byrne, Barbara A
AU - Wetzlich, S. E.
AU - Kieu, H. T.
AU - Tell, Lisa A
PY - 2013/4
Y1 - 2013/4
N2 - Six adult male alpacas received one subcutaneous administration of ceftiofur crystalline free acid (CCFA) at a dosage of 6.6mg/kg. After a washout period, the same alpacas received three subcutaneous doses of 6.6mg/kg CCFA at 5-day intervals. Blood samples collected from the jugular vein before and at multiple time points after each CCFA administration were assayed for ceftiofur- and desfuroylceftiofur-related metabolite concentrations using high-performance liquid chromatography. Pharmacokinetic disposition of CCFA was analyzed by a noncompartmental approach. Mean pharmacokinetic parameters (±SD) following single-dose administration of CCFA were Cmax (2.7±0.9μg/mL); Tmax (36±0h); area under the curve AUC0→∞ (199.2±42.1μg·h/mL); terminal phase rate constant λz (0.02±0.003/h); and terminal phase rate constant half-life t1/2λz (44.7h; harmonic). Mean terminal pharmacokinetic parameters (±SD) following three administrations of CCFA were Cmax (2.0±0.4μg/mL); Tmax (17.3±16.3h); AUC0→∞ (216.8±84.5μg·h/mL); λz (0.01±0.003/h); and t1/2λz (65.9h; harmonic). The terminal phase rate constant and the Tmax were significantly different between single and multiple administrations. Local reactions were noted in two alpacas following multiple CCFA administrations.
AB - Six adult male alpacas received one subcutaneous administration of ceftiofur crystalline free acid (CCFA) at a dosage of 6.6mg/kg. After a washout period, the same alpacas received three subcutaneous doses of 6.6mg/kg CCFA at 5-day intervals. Blood samples collected from the jugular vein before and at multiple time points after each CCFA administration were assayed for ceftiofur- and desfuroylceftiofur-related metabolite concentrations using high-performance liquid chromatography. Pharmacokinetic disposition of CCFA was analyzed by a noncompartmental approach. Mean pharmacokinetic parameters (±SD) following single-dose administration of CCFA were Cmax (2.7±0.9μg/mL); Tmax (36±0h); area under the curve AUC0→∞ (199.2±42.1μg·h/mL); terminal phase rate constant λz (0.02±0.003/h); and terminal phase rate constant half-life t1/2λz (44.7h; harmonic). Mean terminal pharmacokinetic parameters (±SD) following three administrations of CCFA were Cmax (2.0±0.4μg/mL); Tmax (17.3±16.3h); AUC0→∞ (216.8±84.5μg·h/mL); λz (0.01±0.003/h); and t1/2λz (65.9h; harmonic). The terminal phase rate constant and the Tmax were significantly different between single and multiple administrations. Local reactions were noted in two alpacas following multiple CCFA administrations.
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UR - http://www.scopus.com/inward/citedby.url?scp=84874932665&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2885.2012.01395.x
DO - 10.1111/j.1365-2885.2012.01395.x
M3 - Article
VL - 36
SP - 122
EP - 129
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
SN - 0140-7783
IS - 2
ER -