Six adult male alpacas received one subcutaneous administration of ceftiofur crystalline free acid (CCFA) at a dosage of 6.6mg/kg. After a washout period, the same alpacas received three subcutaneous doses of 6.6mg/kg CCFA at 5-day intervals. Blood samples collected from the jugular vein before and at multiple time points after each CCFA administration were assayed for ceftiofur- and desfuroylceftiofur-related metabolite concentrations using high-performance liquid chromatography. Pharmacokinetic disposition of CCFA was analyzed by a noncompartmental approach. Mean pharmacokinetic parameters (±SD) following single-dose administration of CCFA were Cmax (2.7±0.9μg/mL); Tmax (36±0h); area under the curve AUC0→∞ (199.2±42.1μg·h/mL); terminal phase rate constant λz (0.02±0.003/h); and terminal phase rate constant half-life t1/2λz (44.7h; harmonic). Mean terminal pharmacokinetic parameters (±SD) following three administrations of CCFA were Cmax (2.0±0.4μg/mL); Tmax (17.3±16.3h); AUC0→∞ (216.8±84.5μg·h/mL); λz (0.01±0.003/h); and t1/2λz (65.9h; harmonic). The terminal phase rate constant and the Tmax were significantly different between single and multiple administrations. Local reactions were noted in two alpacas following multiple CCFA administrations.
|Original language||English (US)|
|Number of pages||8|
|Journal||Journal of Veterinary Pharmacology and Therapeutics|
|State||Published - Apr 2013|
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