Pharmacokinetics of ceftiofur crystalline free acid after single and multiple subcutaneous administrations in healthy alpacas (Vicugna pacos)

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Abstract

Six adult male alpacas received one subcutaneous administration of ceftiofur crystalline free acid (CCFA) at a dosage of 6.6mg/kg. After a washout period, the same alpacas received three subcutaneous doses of 6.6mg/kg CCFA at 5-day intervals. Blood samples collected from the jugular vein before and at multiple time points after each CCFA administration were assayed for ceftiofur- and desfuroylceftiofur-related metabolite concentrations using high-performance liquid chromatography. Pharmacokinetic disposition of CCFA was analyzed by a noncompartmental approach. Mean pharmacokinetic parameters (±SD) following single-dose administration of CCFA were Cmax (2.7±0.9μg/mL); Tmax (36±0h); area under the curve AUC0→∞ (199.2±42.1μg·h/mL); terminal phase rate constant λz (0.02±0.003/h); and terminal phase rate constant half-life t1/2λz (44.7h; harmonic). Mean terminal pharmacokinetic parameters (±SD) following three administrations of CCFA were Cmax (2.0±0.4μg/mL); Tmax (17.3±16.3h); AUC0→∞ (216.8±84.5μg·h/mL); λz (0.01±0.003/h); and t1/2λz (65.9h; harmonic). The terminal phase rate constant and the Tmax were significantly different between single and multiple administrations. Local reactions were noted in two alpacas following multiple CCFA administrations.

Original languageEnglish (US)
Pages (from-to)122-129
Number of pages8
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume36
Issue number2
DOIs
StatePublished - Apr 2013

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New World Camelids
ceftiofur
alpacas
subcutaneous injection
pharmacokinetics
Pharmacokinetics
Acids
acids
dosage
Vicugna pacos
Jugular Veins
jugular vein
half life
Area Under Curve
Half-Life
high performance liquid chromatography
High Pressure Liquid Chromatography
metabolites
blood

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

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title = "Pharmacokinetics of ceftiofur crystalline free acid after single and multiple subcutaneous administrations in healthy alpacas (Vicugna pacos)",
abstract = "Six adult male alpacas received one subcutaneous administration of ceftiofur crystalline free acid (CCFA) at a dosage of 6.6mg/kg. After a washout period, the same alpacas received three subcutaneous doses of 6.6mg/kg CCFA at 5-day intervals. Blood samples collected from the jugular vein before and at multiple time points after each CCFA administration were assayed for ceftiofur- and desfuroylceftiofur-related metabolite concentrations using high-performance liquid chromatography. Pharmacokinetic disposition of CCFA was analyzed by a noncompartmental approach. Mean pharmacokinetic parameters (±SD) following single-dose administration of CCFA were Cmax (2.7±0.9μg/mL); Tmax (36±0h); area under the curve AUC0→∞ (199.2±42.1μg·h/mL); terminal phase rate constant λz (0.02±0.003/h); and terminal phase rate constant half-life t1/2λz (44.7h; harmonic). Mean terminal pharmacokinetic parameters (±SD) following three administrations of CCFA were Cmax (2.0±0.4μg/mL); Tmax (17.3±16.3h); AUC0→∞ (216.8±84.5μg·h/mL); λz (0.01±0.003/h); and t1/2λz (65.9h; harmonic). The terminal phase rate constant and the Tmax were significantly different between single and multiple administrations. Local reactions were noted in two alpacas following multiple CCFA administrations.",
author = "Dechant, {Julie E} and Rowe, {Joan D} and Byrne, {Barbara A} and Wetzlich, {S. E.} and Kieu, {H. T.} and Tell, {Lisa A}",
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T1 - Pharmacokinetics of ceftiofur crystalline free acid after single and multiple subcutaneous administrations in healthy alpacas (Vicugna pacos)

AU - Dechant, Julie E

AU - Rowe, Joan D

AU - Byrne, Barbara A

AU - Wetzlich, S. E.

AU - Kieu, H. T.

AU - Tell, Lisa A

PY - 2013/4

Y1 - 2013/4

N2 - Six adult male alpacas received one subcutaneous administration of ceftiofur crystalline free acid (CCFA) at a dosage of 6.6mg/kg. After a washout period, the same alpacas received three subcutaneous doses of 6.6mg/kg CCFA at 5-day intervals. Blood samples collected from the jugular vein before and at multiple time points after each CCFA administration were assayed for ceftiofur- and desfuroylceftiofur-related metabolite concentrations using high-performance liquid chromatography. Pharmacokinetic disposition of CCFA was analyzed by a noncompartmental approach. Mean pharmacokinetic parameters (±SD) following single-dose administration of CCFA were Cmax (2.7±0.9μg/mL); Tmax (36±0h); area under the curve AUC0→∞ (199.2±42.1μg·h/mL); terminal phase rate constant λz (0.02±0.003/h); and terminal phase rate constant half-life t1/2λz (44.7h; harmonic). Mean terminal pharmacokinetic parameters (±SD) following three administrations of CCFA were Cmax (2.0±0.4μg/mL); Tmax (17.3±16.3h); AUC0→∞ (216.8±84.5μg·h/mL); λz (0.01±0.003/h); and t1/2λz (65.9h; harmonic). The terminal phase rate constant and the Tmax were significantly different between single and multiple administrations. Local reactions were noted in two alpacas following multiple CCFA administrations.

AB - Six adult male alpacas received one subcutaneous administration of ceftiofur crystalline free acid (CCFA) at a dosage of 6.6mg/kg. After a washout period, the same alpacas received three subcutaneous doses of 6.6mg/kg CCFA at 5-day intervals. Blood samples collected from the jugular vein before and at multiple time points after each CCFA administration were assayed for ceftiofur- and desfuroylceftiofur-related metabolite concentrations using high-performance liquid chromatography. Pharmacokinetic disposition of CCFA was analyzed by a noncompartmental approach. Mean pharmacokinetic parameters (±SD) following single-dose administration of CCFA were Cmax (2.7±0.9μg/mL); Tmax (36±0h); area under the curve AUC0→∞ (199.2±42.1μg·h/mL); terminal phase rate constant λz (0.02±0.003/h); and terminal phase rate constant half-life t1/2λz (44.7h; harmonic). Mean terminal pharmacokinetic parameters (±SD) following three administrations of CCFA were Cmax (2.0±0.4μg/mL); Tmax (17.3±16.3h); AUC0→∞ (216.8±84.5μg·h/mL); λz (0.01±0.003/h); and t1/2λz (65.9h; harmonic). The terminal phase rate constant and the Tmax were significantly different between single and multiple administrations. Local reactions were noted in two alpacas following multiple CCFA administrations.

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DO - 10.1111/j.1365-2885.2012.01395.x

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JF - Journal of Veterinary Pharmacology and Therapeutics

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