Pharmacokinetics of a single intramuscular injection of ceftiofur crystalline-free acid in American black ducks (Anas rubripes)

Katharine L. Hope, Lisa A Tell, Barbara A Byrne, Suzan Murray, Scott E. Wetzlich, Lisa H. Ware, Warren Lynch, Luis R. Padilla, Nancy C. Boedeker

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective-To determine the pharmacokinetic properties of 1 IM injection of ceftiofur crystalline- free acid (CCFA) in American black ducks (Anas rubripes). Animals-20 adult American black ducks (6 in a preliminary experiment and 14 in a primary experiment). Procedures-Dose and route of administration of CCFA for the primary experiment were determined in a preliminary experiment. In the primary experiment, CCFA (10 mg/kg, IM) was administered to ducks. Ducks were allocated into 2 groups, and blood samples were obtained 0.25, 0.5, 1, 2, 4, 8, 12, 48, 96, 144, 192, and 240 hours or 0.25, 0.5, 1, 2, 4, 8, 24, 72, 120, 168, and 216 hours after administration of CCFA. Plasma concentrations of ceftiofur free acid equivalents (CFAEs) were determined by use of high-performance liquid chromatography. Data were evaluated by use of a naive pooled-data approach. Results-The area under the plasma concentration versus time curve from 0 hours to infinity was 783 h•μg/mL, maximum plasma concentration observed was 13.1 μg/mL, time to maximum plasma concentration observed was 24 hours, terminal phase half-life was 32.0 hours, time that concentrations of CFAEs were higher than the minimum inhibitory concentration (1.0 μg/mL) for many pathogens of birds was 123 hours, and time that concentrations of CFAEs were higher than the target plasma concentration (4.0 μg/mL) was 73.3 hours. Conclusions and Clinical Relevance-On the basis of the time that CFAE concentrations were higher than the target plasma concentration, a dosing interval of 3 days can be recommended for future multidose CCFA studies.

Original languageEnglish (US)
Pages (from-to)620-627
Number of pages8
JournalAmerican Journal of Veterinary Research
Volume73
Issue number5
DOIs
StatePublished - May 2012

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ceftiofur
Ducks
Intramuscular Injections
intramuscular injection
pharmacokinetics
Pharmacokinetics
Acids
acids
ducks
Anas rubripes
Microbial Sensitivity Tests
Blood Group Antigens
minimum inhibitory concentration
half life
Birds
Half-Life
high performance liquid chromatography
High Pressure Liquid Chromatography
injection
Injections

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Pharmacokinetics of a single intramuscular injection of ceftiofur crystalline-free acid in American black ducks (Anas rubripes). / Hope, Katharine L.; Tell, Lisa A; Byrne, Barbara A; Murray, Suzan; Wetzlich, Scott E.; Ware, Lisa H.; Lynch, Warren; Padilla, Luis R.; Boedeker, Nancy C.

In: American Journal of Veterinary Research, Vol. 73, No. 5, 05.2012, p. 620-627.

Research output: Contribution to journalArticle

Hope, Katharine L. ; Tell, Lisa A ; Byrne, Barbara A ; Murray, Suzan ; Wetzlich, Scott E. ; Ware, Lisa H. ; Lynch, Warren ; Padilla, Luis R. ; Boedeker, Nancy C. / Pharmacokinetics of a single intramuscular injection of ceftiofur crystalline-free acid in American black ducks (Anas rubripes). In: American Journal of Veterinary Research. 2012 ; Vol. 73, No. 5. pp. 620-627.
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abstract = "Objective-To determine the pharmacokinetic properties of 1 IM injection of ceftiofur crystalline- free acid (CCFA) in American black ducks (Anas rubripes). Animals-20 adult American black ducks (6 in a preliminary experiment and 14 in a primary experiment). Procedures-Dose and route of administration of CCFA for the primary experiment were determined in a preliminary experiment. In the primary experiment, CCFA (10 mg/kg, IM) was administered to ducks. Ducks were allocated into 2 groups, and blood samples were obtained 0.25, 0.5, 1, 2, 4, 8, 12, 48, 96, 144, 192, and 240 hours or 0.25, 0.5, 1, 2, 4, 8, 24, 72, 120, 168, and 216 hours after administration of CCFA. Plasma concentrations of ceftiofur free acid equivalents (CFAEs) were determined by use of high-performance liquid chromatography. Data were evaluated by use of a naive pooled-data approach. Results-The area under the plasma concentration versus time curve from 0 hours to infinity was 783 h•μg/mL, maximum plasma concentration observed was 13.1 μg/mL, time to maximum plasma concentration observed was 24 hours, terminal phase half-life was 32.0 hours, time that concentrations of CFAEs were higher than the minimum inhibitory concentration (1.0 μg/mL) for many pathogens of birds was 123 hours, and time that concentrations of CFAEs were higher than the target plasma concentration (4.0 μg/mL) was 73.3 hours. Conclusions and Clinical Relevance-On the basis of the time that CFAE concentrations were higher than the target plasma concentration, a dosing interval of 3 days can be recommended for future multidose CCFA studies.",
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AU - Tell, Lisa A

AU - Byrne, Barbara A

AU - Murray, Suzan

AU - Wetzlich, Scott E.

AU - Ware, Lisa H.

AU - Lynch, Warren

AU - Padilla, Luis R.

AU - Boedeker, Nancy C.

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AB - Objective-To determine the pharmacokinetic properties of 1 IM injection of ceftiofur crystalline- free acid (CCFA) in American black ducks (Anas rubripes). Animals-20 adult American black ducks (6 in a preliminary experiment and 14 in a primary experiment). Procedures-Dose and route of administration of CCFA for the primary experiment were determined in a preliminary experiment. In the primary experiment, CCFA (10 mg/kg, IM) was administered to ducks. Ducks were allocated into 2 groups, and blood samples were obtained 0.25, 0.5, 1, 2, 4, 8, 12, 48, 96, 144, 192, and 240 hours or 0.25, 0.5, 1, 2, 4, 8, 24, 72, 120, 168, and 216 hours after administration of CCFA. Plasma concentrations of ceftiofur free acid equivalents (CFAEs) were determined by use of high-performance liquid chromatography. Data were evaluated by use of a naive pooled-data approach. Results-The area under the plasma concentration versus time curve from 0 hours to infinity was 783 h•μg/mL, maximum plasma concentration observed was 13.1 μg/mL, time to maximum plasma concentration observed was 24 hours, terminal phase half-life was 32.0 hours, time that concentrations of CFAEs were higher than the minimum inhibitory concentration (1.0 μg/mL) for many pathogens of birds was 123 hours, and time that concentrations of CFAEs were higher than the target plasma concentration (4.0 μg/mL) was 73.3 hours. Conclusions and Clinical Relevance-On the basis of the time that CFAE concentrations were higher than the target plasma concentration, a dosing interval of 3 days can be recommended for future multidose CCFA studies.

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