Abstract
Yamarik, T. A., Wilson, W. D., Wiebe, V. J., Pusterla, N., Edman, J., Papich, M. G. Pharmacokinetics and toxicity of ciprofloxacin in adult horses. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2010.01167.x.Using a randomized, cross-over study design, ciprofloxacin was administered i.g. to eight adult mares at a dose of 20-mg/kg, and to seven of the eight horses at a dose of 5-mg/kg by bolus i.v. injection. The mean C0 was 20.5-μg/mL (±8.8) immediately after i.v. administration. The Cmax was 0.6-μg/mL (±0.36) at Tmax 1.46-(±0.66)-h after the administration of oral ciprofloxacin. The mean elimination half-life after i.v. administration was 5.8-(±1.6)-h, and after oral administration the terminal half-life was 3.6-(±1.7)-h. The overall mean systemic availability of the oral dose was 10.5-(±2.8)%. Transient adverse effects of mild to moderate severity included agitation, excitement and muscle fasciculation, followed by lethargy, cutaneous edema and loss of appetite developed in all seven horses after i.v. administration. All seven horses developed mild transient diarrhea at 36-48 after i.v. dosing. All eight horses dosed intragastrically experienced adverse events attributable to ciprofloxacin administration. Adverse events included mild transient diarrhea to severe colitis, endotoxemia and laminitis necessitating euthanasia of three horses on humane grounds. The high incidences of adverse events preclude oral and rapid i.v. push administration of ciprofloxacin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 587-594 |
| Number of pages | 8 |
| Journal | Journal of Veterinary Pharmacology and Therapeutics |
| Volume | 33 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2010 |
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ASJC Scopus subject areas
- Pharmacology
- veterinary(all)
Cite this
Pharmacokinetics and toxicity of ciprofloxacin in adult horses. / Yamarik, T. A.; Wilson, William D; Wiebe, V. J.; Pusterla, Nicola; Edman, J.; Papich, M. G.
In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 33, No. 6, 12.2010, p. 587-594.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics and toxicity of ciprofloxacin in adult horses
AU - Yamarik, T. A.
AU - Wilson, William D
AU - Wiebe, V. J.
AU - Pusterla, Nicola
AU - Edman, J.
AU - Papich, M. G.
PY - 2010/12
Y1 - 2010/12
N2 - Yamarik, T. A., Wilson, W. D., Wiebe, V. J., Pusterla, N., Edman, J., Papich, M. G. Pharmacokinetics and toxicity of ciprofloxacin in adult horses. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2010.01167.x.Using a randomized, cross-over study design, ciprofloxacin was administered i.g. to eight adult mares at a dose of 20-mg/kg, and to seven of the eight horses at a dose of 5-mg/kg by bolus i.v. injection. The mean C0 was 20.5-μg/mL (±8.8) immediately after i.v. administration. The Cmax was 0.6-μg/mL (±0.36) at Tmax 1.46-(±0.66)-h after the administration of oral ciprofloxacin. The mean elimination half-life after i.v. administration was 5.8-(±1.6)-h, and after oral administration the terminal half-life was 3.6-(±1.7)-h. The overall mean systemic availability of the oral dose was 10.5-(±2.8)%. Transient adverse effects of mild to moderate severity included agitation, excitement and muscle fasciculation, followed by lethargy, cutaneous edema and loss of appetite developed in all seven horses after i.v. administration. All seven horses developed mild transient diarrhea at 36-48 after i.v. dosing. All eight horses dosed intragastrically experienced adverse events attributable to ciprofloxacin administration. Adverse events included mild transient diarrhea to severe colitis, endotoxemia and laminitis necessitating euthanasia of three horses on humane grounds. The high incidences of adverse events preclude oral and rapid i.v. push administration of ciprofloxacin.
AB - Yamarik, T. A., Wilson, W. D., Wiebe, V. J., Pusterla, N., Edman, J., Papich, M. G. Pharmacokinetics and toxicity of ciprofloxacin in adult horses. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2010.01167.x.Using a randomized, cross-over study design, ciprofloxacin was administered i.g. to eight adult mares at a dose of 20-mg/kg, and to seven of the eight horses at a dose of 5-mg/kg by bolus i.v. injection. The mean C0 was 20.5-μg/mL (±8.8) immediately after i.v. administration. The Cmax was 0.6-μg/mL (±0.36) at Tmax 1.46-(±0.66)-h after the administration of oral ciprofloxacin. The mean elimination half-life after i.v. administration was 5.8-(±1.6)-h, and after oral administration the terminal half-life was 3.6-(±1.7)-h. The overall mean systemic availability of the oral dose was 10.5-(±2.8)%. Transient adverse effects of mild to moderate severity included agitation, excitement and muscle fasciculation, followed by lethargy, cutaneous edema and loss of appetite developed in all seven horses after i.v. administration. All seven horses developed mild transient diarrhea at 36-48 after i.v. dosing. All eight horses dosed intragastrically experienced adverse events attributable to ciprofloxacin administration. Adverse events included mild transient diarrhea to severe colitis, endotoxemia and laminitis necessitating euthanasia of three horses on humane grounds. The high incidences of adverse events preclude oral and rapid i.v. push administration of ciprofloxacin.
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U2 - 10.1111/j.1365-2885.2010.01167.x
DO - 10.1111/j.1365-2885.2010.01167.x
M3 - Article
C2 - 21062312
AN - SCOPUS:78349296061
VL - 33
SP - 587
EP - 594
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
SN - 0140-7783
IS - 6
ER -