Pharmacokinetics and preliminary safety evaluation of azithromycin in adult horses

M. Leclere, K G Magdesian, C. A. Cole, N. J. Szabo, R. E. Ruby, D. M. Rhodes, J. Edman, A. Vale, William D Wilson, Lisa A Tell

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Azithromycin is widely used in foals but has not been studied in adult horses. The goals of this study were to determine the pharmacokinetic profile and to make a preliminary assessment of the safety of azithromycin in adult horses. Azithromycin was administered intravenously (5mg/kg) and intragastrically (10mg/kg) to six healthy mares in a crossover design. Serial plasma samples, blood neutrophils, and pulmonary macrophages were collected for the measurement of azithromycin concentrations. Azithromycin was also administered orally (10mg/kg) once a day for 5days to five healthy mares for preliminary evaluation of safety in adult horses. The bioavailability of azithromycin following intragastric administration was 45±12%. Concentrations within peripheral neutrophils and bronchoalveolar macrophages were several fold higher than that of plasma. Mild decreases in appetite (n=3) and alterations in fecal consistency (n=3) were noted following repeated oral administration. The pharmacokinetic profiles of azithromycin in adult horses, especially the slow elimination rate and intraneutrophil and intrapulmonary macrophage accumulation, demonstrate that it is conducive to use in this age group. Because of the gastrointestinal alterations noted, further studies are warranted before azithromycin can be recommended for use in adult horses.

Original languageEnglish (US)
Pages (from-to)541-549
Number of pages9
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume35
Issue number6
DOIs
StatePublished - Dec 2012

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azithromycin
Azithromycin
pharmacokinetics
Horses
Pharmacokinetics
Safety
horses
macrophages
mares
neutrophils
Neutrophils
Macrophages
intragastric administration
safety assessment
Alveolar Macrophages
Appetite
appetite
foals
Cross-Over Studies
oral administration

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

Pharmacokinetics and preliminary safety evaluation of azithromycin in adult horses. / Leclere, M.; Magdesian, K G; Cole, C. A.; Szabo, N. J.; Ruby, R. E.; Rhodes, D. M.; Edman, J.; Vale, A.; Wilson, William D; Tell, Lisa A.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 35, No. 6, 12.2012, p. 541-549.

Research output: Contribution to journalArticle

Leclere, M. ; Magdesian, K G ; Cole, C. A. ; Szabo, N. J. ; Ruby, R. E. ; Rhodes, D. M. ; Edman, J. ; Vale, A. ; Wilson, William D ; Tell, Lisa A. / Pharmacokinetics and preliminary safety evaluation of azithromycin in adult horses. In: Journal of Veterinary Pharmacology and Therapeutics. 2012 ; Vol. 35, No. 6. pp. 541-549.
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