Pharmacokinetics and physiological effects of intravenous hydromorphone in conscious dogs

A. G P Guedes, M. G. Papich, E. P. Rude, M. A. Rider

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

This study evaluated the pharmacokinetics, the sedative and anti-nociceptive effects of intravenous hydromorphone in dogs. Five adult dogs were administered hydromorphone (0.1 mg/kg and 0.2 mg/kg) and morphine (0.5 mg/kg and 1 mg/kg) at weekly intervals. Blood samples were drawn before and at 1, 2, 5, 15, 30, 60 and 120 min after drug administration. Plasma hydromorphone only was measured by high pressure liquid chromatography (HPLC) with electrochemical detection and pharmacokinetic parameters calculated. Anti-nociceptive and sedation scores were submitted to Kruskal-Wallis one-way anova on ranks and post-hoc Bonferroni test with 5% significance level. The data fitted a two-compartment model with a fast distribution (<1 min for both doses) and slower elimination rate. Mean elimination half-life was 80 ± 52.7 and 57.7 ± 30.4 min for the high and low dose, respectively. The apparent mean volumes of distribution at steady-state were 7.2 ± 3 and 4.5 ± 2.4 L/kg, while the clearance was 74.7 ± 19 and 68.1 ± 20 mL/kg/min for the high and low doses, respectively. Compared to saline, hydromorphone and morphine produced significant anti-nociception and sedation of similar magnitude for 120 min. In conclusion, intravenous hydromorphone has a large volume of distribution, and high clearance rate that exceeds hepatic blood flow. In dogs, it produced mechanical anti-nociception and sedation of a magnitude similar to morphine.

Original languageEnglish (US)
Pages (from-to)334-343
Number of pages10
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume31
Issue number4
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Hydromorphone
morphine
sedation
pharmacokinetics
nociception
Pharmacokinetics
Dogs
dogs
Morphine
dosage
Nociception
sedatives
analgesic effect
blood flow
half life
high performance liquid chromatography
drugs
liver
Hypnotics and Sedatives
blood

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

Pharmacokinetics and physiological effects of intravenous hydromorphone in conscious dogs. / Guedes, A. G P; Papich, M. G.; Rude, E. P.; Rider, M. A.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 31, No. 4, 08.2008, p. 334-343.

Research output: Contribution to journalArticle

Guedes, A. G P ; Papich, M. G. ; Rude, E. P. ; Rider, M. A. / Pharmacokinetics and physiological effects of intravenous hydromorphone in conscious dogs. In: Journal of Veterinary Pharmacology and Therapeutics. 2008 ; Vol. 31, No. 4. pp. 334-343.
@article{20bd5c9a2e59456d8ccb13af3c183c03,
title = "Pharmacokinetics and physiological effects of intravenous hydromorphone in conscious dogs",
abstract = "This study evaluated the pharmacokinetics, the sedative and anti-nociceptive effects of intravenous hydromorphone in dogs. Five adult dogs were administered hydromorphone (0.1 mg/kg and 0.2 mg/kg) and morphine (0.5 mg/kg and 1 mg/kg) at weekly intervals. Blood samples were drawn before and at 1, 2, 5, 15, 30, 60 and 120 min after drug administration. Plasma hydromorphone only was measured by high pressure liquid chromatography (HPLC) with electrochemical detection and pharmacokinetic parameters calculated. Anti-nociceptive and sedation scores were submitted to Kruskal-Wallis one-way anova on ranks and post-hoc Bonferroni test with 5{\%} significance level. The data fitted a two-compartment model with a fast distribution (<1 min for both doses) and slower elimination rate. Mean elimination half-life was 80 ± 52.7 and 57.7 ± 30.4 min for the high and low dose, respectively. The apparent mean volumes of distribution at steady-state were 7.2 ± 3 and 4.5 ± 2.4 L/kg, while the clearance was 74.7 ± 19 and 68.1 ± 20 mL/kg/min for the high and low doses, respectively. Compared to saline, hydromorphone and morphine produced significant anti-nociception and sedation of similar magnitude for 120 min. In conclusion, intravenous hydromorphone has a large volume of distribution, and high clearance rate that exceeds hepatic blood flow. In dogs, it produced mechanical anti-nociception and sedation of a magnitude similar to morphine.",
author = "Guedes, {A. G P} and Papich, {M. G.} and Rude, {E. P.} and Rider, {M. A.}",
year = "2008",
month = "8",
doi = "10.1111/j.1365-2885.2008.00966.x",
language = "English (US)",
volume = "31",
pages = "334--343",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
issn = "0140-7783",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Pharmacokinetics and physiological effects of intravenous hydromorphone in conscious dogs

AU - Guedes, A. G P

AU - Papich, M. G.

AU - Rude, E. P.

AU - Rider, M. A.

PY - 2008/8

Y1 - 2008/8

N2 - This study evaluated the pharmacokinetics, the sedative and anti-nociceptive effects of intravenous hydromorphone in dogs. Five adult dogs were administered hydromorphone (0.1 mg/kg and 0.2 mg/kg) and morphine (0.5 mg/kg and 1 mg/kg) at weekly intervals. Blood samples were drawn before and at 1, 2, 5, 15, 30, 60 and 120 min after drug administration. Plasma hydromorphone only was measured by high pressure liquid chromatography (HPLC) with electrochemical detection and pharmacokinetic parameters calculated. Anti-nociceptive and sedation scores were submitted to Kruskal-Wallis one-way anova on ranks and post-hoc Bonferroni test with 5% significance level. The data fitted a two-compartment model with a fast distribution (<1 min for both doses) and slower elimination rate. Mean elimination half-life was 80 ± 52.7 and 57.7 ± 30.4 min for the high and low dose, respectively. The apparent mean volumes of distribution at steady-state were 7.2 ± 3 and 4.5 ± 2.4 L/kg, while the clearance was 74.7 ± 19 and 68.1 ± 20 mL/kg/min for the high and low doses, respectively. Compared to saline, hydromorphone and morphine produced significant anti-nociception and sedation of similar magnitude for 120 min. In conclusion, intravenous hydromorphone has a large volume of distribution, and high clearance rate that exceeds hepatic blood flow. In dogs, it produced mechanical anti-nociception and sedation of a magnitude similar to morphine.

AB - This study evaluated the pharmacokinetics, the sedative and anti-nociceptive effects of intravenous hydromorphone in dogs. Five adult dogs were administered hydromorphone (0.1 mg/kg and 0.2 mg/kg) and morphine (0.5 mg/kg and 1 mg/kg) at weekly intervals. Blood samples were drawn before and at 1, 2, 5, 15, 30, 60 and 120 min after drug administration. Plasma hydromorphone only was measured by high pressure liquid chromatography (HPLC) with electrochemical detection and pharmacokinetic parameters calculated. Anti-nociceptive and sedation scores were submitted to Kruskal-Wallis one-way anova on ranks and post-hoc Bonferroni test with 5% significance level. The data fitted a two-compartment model with a fast distribution (<1 min for both doses) and slower elimination rate. Mean elimination half-life was 80 ± 52.7 and 57.7 ± 30.4 min for the high and low dose, respectively. The apparent mean volumes of distribution at steady-state were 7.2 ± 3 and 4.5 ± 2.4 L/kg, while the clearance was 74.7 ± 19 and 68.1 ± 20 mL/kg/min for the high and low doses, respectively. Compared to saline, hydromorphone and morphine produced significant anti-nociception and sedation of similar magnitude for 120 min. In conclusion, intravenous hydromorphone has a large volume of distribution, and high clearance rate that exceeds hepatic blood flow. In dogs, it produced mechanical anti-nociception and sedation of a magnitude similar to morphine.

UR - http://www.scopus.com/inward/record.url?scp=47349128049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47349128049&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2885.2008.00966.x

DO - 10.1111/j.1365-2885.2008.00966.x

M3 - Article

C2 - 18638294

AN - SCOPUS:47349128049

VL - 31

SP - 334

EP - 343

JO - Journal of Veterinary Pharmacology and Therapeutics

JF - Journal of Veterinary Pharmacology and Therapeutics

SN - 0140-7783

IS - 4

ER -