Pharmacokinetics and pharmacodynamics of the glucagon-like peptide-1 analog liraglutide in healthy cats

M. J. Hall, C. A. Adin, S. Borin-Crivellenti, A. J. Rudinsky, P. Rajala-Schultz, J. Lakritz, Chen Gilor

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Glucagon-like peptide-1 (GLP-1) is an intestinal hormone that induces glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion. Glucagon-like peptide-1 also increases beta cell mass and satiation while decelerating gastric emptying. Liraglutide is a fatty-acid derivative of GLP-1 with a protracted pharmacokinetic profile that is used in people for treatment of type II diabetes mellitus and obesity. The aim of this study was to determine the pharmacokinetics and pharmacodynamics of liraglutide in healthy cats. Hyperglycemic clamps were performed on days 0 (HGC) and 14 (LgHGC) in 7 healthy cats. Liraglutide was administered subcutaneously (0.6mg/cat) once daily ondays 8 through 14. Compared with the HGC (mean ± standard deviation; 455.5 ± 115.8ng/L), insulin concentrations during LgHGC were increased (760.8 ± 350.7ng/L; P=0.0022), glucagon concentrations decreased (0.66 ± 0.4 pmol/L during HGC vs 0.5 ± 0.4 pmol/L during LgHGC; P = 0.0089), and there was a trend toward an increased total glucose infused (median [range] = 1.61 (1.11-2.54) g/kg and 2.25 (1.64-3.10) g/kg, respectively; P = 0.087). Appetite reduction and decreased body weight (9% ± 3%; P = 0.006) were observed in all cats. Liraglutide has similar effects and pharmacokinetics profile in cats to those reported in people. With a half-life of approximately 12h, once daily dosing might be feasible; however, significant effects on appetite and weight loss may necessitate dosage or dosing frequency reductions. Further investigation of liraglutide in diabetic cats and overweight cats is warranted.

Original languageEnglish (US)
Pages (from-to)114-121
Number of pages8
JournalDomestic Animal Endocrinology
Volume51
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

Keywords

  • Diabetes
  • Feline
  • Glucagon
  • Incretin
  • Insulin

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology
  • Food Animals
  • Medicine(all)

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