Pharmacokinetics and distribution of voriconazole in body fluids of dogs after repeated oral dosing

Julie Denise Lemetayer, P. M. Dowling, S. M. Taylor, M. G. Papich

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The goal of this project was to determine the pharmacokinetics of voriconazole and its concentration in cerebrospinal fluid (CSF), aqueous humor, and synovial fluid in five healthy dogs following once daily oral dose of 6 mg/kg for 2 weeks. Body fluid and plasma drug concentrations were determined by high-performance liquid chromatography (HPLC). Mild to moderate gastrointestinal adverse effects were seen. The mean AUC0-24: minimum inhibitory concentration (MIC) ratio was 15.23 for a chosen MIC of 1 μg/mL, which is lower than the recommended target of 20-25 and also lower than previously reported in dogs, perhaps reflecting induction of metabolizing enzymes by multiple dosing. Voriconazole concentrations in the CSF, aqueous humor, and synovial fluid were only 13-30% the concurrent plasma concentration, which is lower than previously reported in other species. Results of this study suggest that twice daily, administration may be necessary to maintain therapeutic plasma concentrations in dogs but further studies are warranted.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume38
Issue number5
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

body fluids
Body Fluids
pharmacokinetics
mouth
synovial fluid
Pharmacokinetics
Aqueous Humor
Synovial Fluid
Microbial Sensitivity Tests
cerebrospinal fluid
Dogs
minimum inhibitory concentration
Cerebrospinal Fluid
dogs
Enzyme Induction
gene induction
high performance liquid chromatography
water
adverse effects
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

Pharmacokinetics and distribution of voriconazole in body fluids of dogs after repeated oral dosing. / Lemetayer, Julie Denise; Dowling, P. M.; Taylor, S. M.; Papich, M. G.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 38, No. 5, 01.10.2015, p. 451-456.

Research output: Contribution to journalArticle

Lemetayer, Julie Denise ; Dowling, P. M. ; Taylor, S. M. ; Papich, M. G. / Pharmacokinetics and distribution of voriconazole in body fluids of dogs after repeated oral dosing. In: Journal of Veterinary Pharmacology and Therapeutics. 2015 ; Vol. 38, No. 5. pp. 451-456.
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