Abstract
The purpose of this study was to describe the pharmacokinetics of bromide in horses and to evaluate the corrected bromide space as an indicator of extracellular fluid volume (ECFV) in horses after the administration of a single dose of bromide by intravenous infusion. Sodium bromide (30 mg/kg of body weight, IV) was administered to 6 clinically healthy mares over a period of 3 minutes. Blood samples were collected before infusion and at intervals between 0.5 hours and 53 days after infusion. Mean elimination half-life (harmonic mean) was 126 hours (5.2 days), clearance was 1.4 ± 0.09 mL/kg·h, area under the curve was 17,520 ± 1,100 μg·h/mL, and volume of distribution (steady state) was 0.255 ± 0.015 L/kg. The mean corrected bromide space was determined from the volume of distribution (steady state) and the serum concentrations of bromide at equilibration. Corrected bromide space, an estimate of ECFV, was 0.218 ± 0.01 L/kg. The conclusion was made that ECFV of horses can be estimated by measuring bromide concentrations in a preinfusion serum sample and a sample obtained 5 hours after the administration of bromide.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 213-217 |
| Number of pages | 5 |
| Journal | Journal of Veterinary Internal Medicine |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2003 |
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Keywords
- Fluid balance
- Pharmacology
ASJC Scopus subject areas
- veterinary(all)
Cite this
Pharmacokinetics and Clinical Utility of Sodium Bromide (NaBr) as an Estimator of Extracellular Fluid Volume in Horses. / Fielding, C. Langdon; Magdesian, K G; Elliott, Denise A.; Craigmill, Arthur L.; Wilson, William D; Carlson, Gary.
In: Journal of Veterinary Internal Medicine, Vol. 17, No. 2, 03.2003, p. 213-217.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics and Clinical Utility of Sodium Bromide (NaBr) as an Estimator of Extracellular Fluid Volume in Horses
AU - Fielding, C. Langdon
AU - Magdesian, K G
AU - Elliott, Denise A.
AU - Craigmill, Arthur L.
AU - Wilson, William D
AU - Carlson, Gary
PY - 2003/3
Y1 - 2003/3
N2 - The purpose of this study was to describe the pharmacokinetics of bromide in horses and to evaluate the corrected bromide space as an indicator of extracellular fluid volume (ECFV) in horses after the administration of a single dose of bromide by intravenous infusion. Sodium bromide (30 mg/kg of body weight, IV) was administered to 6 clinically healthy mares over a period of 3 minutes. Blood samples were collected before infusion and at intervals between 0.5 hours and 53 days after infusion. Mean elimination half-life (harmonic mean) was 126 hours (5.2 days), clearance was 1.4 ± 0.09 mL/kg·h, area under the curve was 17,520 ± 1,100 μg·h/mL, and volume of distribution (steady state) was 0.255 ± 0.015 L/kg. The mean corrected bromide space was determined from the volume of distribution (steady state) and the serum concentrations of bromide at equilibration. Corrected bromide space, an estimate of ECFV, was 0.218 ± 0.01 L/kg. The conclusion was made that ECFV of horses can be estimated by measuring bromide concentrations in a preinfusion serum sample and a sample obtained 5 hours after the administration of bromide.
AB - The purpose of this study was to describe the pharmacokinetics of bromide in horses and to evaluate the corrected bromide space as an indicator of extracellular fluid volume (ECFV) in horses after the administration of a single dose of bromide by intravenous infusion. Sodium bromide (30 mg/kg of body weight, IV) was administered to 6 clinically healthy mares over a period of 3 minutes. Blood samples were collected before infusion and at intervals between 0.5 hours and 53 days after infusion. Mean elimination half-life (harmonic mean) was 126 hours (5.2 days), clearance was 1.4 ± 0.09 mL/kg·h, area under the curve was 17,520 ± 1,100 μg·h/mL, and volume of distribution (steady state) was 0.255 ± 0.015 L/kg. The mean corrected bromide space was determined from the volume of distribution (steady state) and the serum concentrations of bromide at equilibration. Corrected bromide space, an estimate of ECFV, was 0.218 ± 0.01 L/kg. The conclusion was made that ECFV of horses can be estimated by measuring bromide concentrations in a preinfusion serum sample and a sample obtained 5 hours after the administration of bromide.
KW - Fluid balance
KW - Pharmacology
UR - http://www.scopus.com/inward/record.url?scp=0038656724&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038656724&partnerID=8YFLogxK
U2 - 10.1892/0891-6640(2003)017<0213:PACUOS>2.3.CO;2
DO - 10.1892/0891-6640(2003)017<0213:PACUOS>2.3.CO;2
M3 - Article
VL - 17
SP - 213
EP - 217
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 2
ER -