Pharmacokinetics and anesthetic and cardiopulmonary effects of propofol in red-tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus)

Michelle Hawkins, Bonnie D. Wright, Peter J Pascoe, Philip H Kass, Lara K. Maxwell, Lisa A Tell

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Abstract

Objective - To determine induction doses, anesthetic constant rate infusions (CRI), and cardiopulmonary effects of propofol in red-tailed hawks and great horned owls and propofol pharmacokinetics in the owls during CRI. Animals - 6 red-tailed hawks and 6 great horned owls, Procedure - The CRI dose necessary for a loss of withdrawal reflex was determined via specific stimuli. Anesthesia was induced by IV administration of propofol (1 mg/kg/min) and maintained by CRI at the predetermined dose for 30 minutes. Heart and respiratory rates, arterial blood pressures, and blood gas tensions were obtained in awake birds and at various times after induction. End-tidal CO2 (ETco2) concentration and esophageal temperature were obtained after induction. Propofol plasma concentrations were obtained after induction and after completion of the CRI in the owls. Recovery times were recorded. Results - Mean ± SD doses for induction and CRI were 4.48 ± 1.09 mg/kg and 0.48 ± 0.06 mg/kg/min, respectively, for hawks and 3.36 ± 0.71 mg/kg and 0.56 ± 0.15 mg/kg/min, respectively, for owls. Significant increases in Paco2, HCO3, and ETco2 in hawks and owls and significant decreases in arterial pH in hawks were detected. A 2-compartment model best described the owl pharmacodynamic data. Recovery times after infusion were prolonged and varied widely. Central nervous system excitatory signs were observed during recovery. Conclusions and Clinical Relevance - Effects on blood pressure were minimal, but effective ventilation was reduced, suggesting the need for careful monitoring during anesthesia. Prolonged recovery periods with moderate-to-severe excitatory CNS signs may occur in these species at these doses.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalAmerican Journal of Veterinary Research
Volume64
Issue number6
DOIs
StatePublished - Jun 1 2003

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Hawks
Bubo virginianus
Strigiformes
Buteo jamaicensis
Propofol
anesthetics
pharmacokinetics
Anesthetics
Pharmacokinetics
hawks
dosage
blood pressure
anesthesia
Anesthesia
blood gases
pharmacology
respiratory rate
reflexes
intravenous injection
central nervous system

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{b4ee3fc8d6c64751bab4bdb268c15ba1,
title = "Pharmacokinetics and anesthetic and cardiopulmonary effects of propofol in red-tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus)",
abstract = "Objective - To determine induction doses, anesthetic constant rate infusions (CRI), and cardiopulmonary effects of propofol in red-tailed hawks and great horned owls and propofol pharmacokinetics in the owls during CRI. Animals - 6 red-tailed hawks and 6 great horned owls, Procedure - The CRI dose necessary for a loss of withdrawal reflex was determined via specific stimuli. Anesthesia was induced by IV administration of propofol (1 mg/kg/min) and maintained by CRI at the predetermined dose for 30 minutes. Heart and respiratory rates, arterial blood pressures, and blood gas tensions were obtained in awake birds and at various times after induction. End-tidal CO2 (ETco2) concentration and esophageal temperature were obtained after induction. Propofol plasma concentrations were obtained after induction and after completion of the CRI in the owls. Recovery times were recorded. Results - Mean ± SD doses for induction and CRI were 4.48 ± 1.09 mg/kg and 0.48 ± 0.06 mg/kg/min, respectively, for hawks and 3.36 ± 0.71 mg/kg and 0.56 ± 0.15 mg/kg/min, respectively, for owls. Significant increases in Paco2, HCO3, and ETco2 in hawks and owls and significant decreases in arterial pH in hawks were detected. A 2-compartment model best described the owl pharmacodynamic data. Recovery times after infusion were prolonged and varied widely. Central nervous system excitatory signs were observed during recovery. Conclusions and Clinical Relevance - Effects on blood pressure were minimal, but effective ventilation was reduced, suggesting the need for careful monitoring during anesthesia. Prolonged recovery periods with moderate-to-severe excitatory CNS signs may occur in these species at these doses.",
author = "Michelle Hawkins and Wright, {Bonnie D.} and Pascoe, {Peter J} and Kass, {Philip H} and Maxwell, {Lara K.} and Tell, {Lisa A}",
year = "2003",
month = "6",
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doi = "10.2460/ajvr.2003.64.677",
language = "English (US)",
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pages = "677--683",
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TY - JOUR

T1 - Pharmacokinetics and anesthetic and cardiopulmonary effects of propofol in red-tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus)

AU - Hawkins, Michelle

AU - Wright, Bonnie D.

AU - Pascoe, Peter J

AU - Kass, Philip H

AU - Maxwell, Lara K.

AU - Tell, Lisa A

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Objective - To determine induction doses, anesthetic constant rate infusions (CRI), and cardiopulmonary effects of propofol in red-tailed hawks and great horned owls and propofol pharmacokinetics in the owls during CRI. Animals - 6 red-tailed hawks and 6 great horned owls, Procedure - The CRI dose necessary for a loss of withdrawal reflex was determined via specific stimuli. Anesthesia was induced by IV administration of propofol (1 mg/kg/min) and maintained by CRI at the predetermined dose for 30 minutes. Heart and respiratory rates, arterial blood pressures, and blood gas tensions were obtained in awake birds and at various times after induction. End-tidal CO2 (ETco2) concentration and esophageal temperature were obtained after induction. Propofol plasma concentrations were obtained after induction and after completion of the CRI in the owls. Recovery times were recorded. Results - Mean ± SD doses for induction and CRI were 4.48 ± 1.09 mg/kg and 0.48 ± 0.06 mg/kg/min, respectively, for hawks and 3.36 ± 0.71 mg/kg and 0.56 ± 0.15 mg/kg/min, respectively, for owls. Significant increases in Paco2, HCO3, and ETco2 in hawks and owls and significant decreases in arterial pH in hawks were detected. A 2-compartment model best described the owl pharmacodynamic data. Recovery times after infusion were prolonged and varied widely. Central nervous system excitatory signs were observed during recovery. Conclusions and Clinical Relevance - Effects on blood pressure were minimal, but effective ventilation was reduced, suggesting the need for careful monitoring during anesthesia. Prolonged recovery periods with moderate-to-severe excitatory CNS signs may occur in these species at these doses.

AB - Objective - To determine induction doses, anesthetic constant rate infusions (CRI), and cardiopulmonary effects of propofol in red-tailed hawks and great horned owls and propofol pharmacokinetics in the owls during CRI. Animals - 6 red-tailed hawks and 6 great horned owls, Procedure - The CRI dose necessary for a loss of withdrawal reflex was determined via specific stimuli. Anesthesia was induced by IV administration of propofol (1 mg/kg/min) and maintained by CRI at the predetermined dose for 30 minutes. Heart and respiratory rates, arterial blood pressures, and blood gas tensions were obtained in awake birds and at various times after induction. End-tidal CO2 (ETco2) concentration and esophageal temperature were obtained after induction. Propofol plasma concentrations were obtained after induction and after completion of the CRI in the owls. Recovery times were recorded. Results - Mean ± SD doses for induction and CRI were 4.48 ± 1.09 mg/kg and 0.48 ± 0.06 mg/kg/min, respectively, for hawks and 3.36 ± 0.71 mg/kg and 0.56 ± 0.15 mg/kg/min, respectively, for owls. Significant increases in Paco2, HCO3, and ETco2 in hawks and owls and significant decreases in arterial pH in hawks were detected. A 2-compartment model best described the owl pharmacodynamic data. Recovery times after infusion were prolonged and varied widely. Central nervous system excitatory signs were observed during recovery. Conclusions and Clinical Relevance - Effects on blood pressure were minimal, but effective ventilation was reduced, suggesting the need for careful monitoring during anesthesia. Prolonged recovery periods with moderate-to-severe excitatory CNS signs may occur in these species at these doses.

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