Abstract
Pharmacokinetic parameters of methadone were studied in adult dairy goats. Five goats were each given methadone hydrochloride as a single 0.2 mg/kg of body weight dosage by intramuscular (IM) administration. Plasma methadone concentrations were determined for 96 h after dosing. Plasma methadone concentrations after IM administration were best described by an open one- compartment model. Overall elimination half-life (t( 1/2 )) was 1.38 h. Peak plasma concentrations were reached 0.25 h after dosing, and the actual plasma concentration averaged 37.8 ng/ml (SD = 12.76) at that time. The data obtained from this study suggest that plasma concentrations, similar to those that are analgesic in humans, can be achieved after IM administration of methadone at a dose rate of 0.2 mg/kg of body weight. In addition, these plasma concentrations can be maintained for up to 3 h after a single injection and, therefore, may provide satisfactory analgesia for such period.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 503-507 |
| Number of pages | 5 |
| Journal | Laboratory Animal Science |
| Volume | 44 |
| Issue number | 5 |
| State | Published - 1994 |
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ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Pharmacokinetic properties of methadone hydrochloride after single intramuscular administration in adult dairy goats. / Kock, M.; Thompson, E.; Vulliet, Philip R; Brooks, D. L.
In: Laboratory Animal Science, Vol. 44, No. 5, 1994, p. 503-507.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetic properties of methadone hydrochloride after single intramuscular administration in adult dairy goats
AU - Kock, M.
AU - Thompson, E.
AU - Vulliet, Philip R
AU - Brooks, D. L.
PY - 1994
Y1 - 1994
N2 - Pharmacokinetic parameters of methadone were studied in adult dairy goats. Five goats were each given methadone hydrochloride as a single 0.2 mg/kg of body weight dosage by intramuscular (IM) administration. Plasma methadone concentrations were determined for 96 h after dosing. Plasma methadone concentrations after IM administration were best described by an open one- compartment model. Overall elimination half-life (t( 1/2 )) was 1.38 h. Peak plasma concentrations were reached 0.25 h after dosing, and the actual plasma concentration averaged 37.8 ng/ml (SD = 12.76) at that time. The data obtained from this study suggest that plasma concentrations, similar to those that are analgesic in humans, can be achieved after IM administration of methadone at a dose rate of 0.2 mg/kg of body weight. In addition, these plasma concentrations can be maintained for up to 3 h after a single injection and, therefore, may provide satisfactory analgesia for such period.
AB - Pharmacokinetic parameters of methadone were studied in adult dairy goats. Five goats were each given methadone hydrochloride as a single 0.2 mg/kg of body weight dosage by intramuscular (IM) administration. Plasma methadone concentrations were determined for 96 h after dosing. Plasma methadone concentrations after IM administration were best described by an open one- compartment model. Overall elimination half-life (t( 1/2 )) was 1.38 h. Peak plasma concentrations were reached 0.25 h after dosing, and the actual plasma concentration averaged 37.8 ng/ml (SD = 12.76) at that time. The data obtained from this study suggest that plasma concentrations, similar to those that are analgesic in humans, can be achieved after IM administration of methadone at a dose rate of 0.2 mg/kg of body weight. In addition, these plasma concentrations can be maintained for up to 3 h after a single injection and, therefore, may provide satisfactory analgesia for such period.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028606907&partnerID=8YFLogxK
M3 - Article
C2 - 7844961
AN - SCOPUS:0028606907
VL - 44
SP - 503
EP - 507
JO - Comparative Medicine
JF - Comparative Medicine
SN - 1532-0820
IS - 5
ER -