Pharmacokinetic Principles for the Design of Intravenous Infusions

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Intravenous infusions are being increasingly used to administer analgesic drugs such as opioids, lidocaine, ketamine, and -2 agonists. Design of intravenous infusions can be either empirical or based on pharmacokinetics. The pharmacokinetic approach is based on the knowledge of the drug concentration that produces the desired effect and the rate at which the drug concentration changes, therefore allowing calculation of the drug dose to be administered in order to maintain target concentration (CT). The simplest form of infusion is a constant rate infusion (CRI). When using pharmacokinetics to establish an appropriate CRI, only two parameters are necessary: CT and the clearance (Cl). An intermediate solution between CRI and target-controlled infusion is the use of sequential CRIs. With this technique, a loading dose is administered, followed by a series of CRIs at decreasing rates, administered for fixed durations.

Original languageEnglish (US)
Title of host publicationPain Management in Veterinary Practice
PublisherWiley Blackwell
Number of pages5
ISBN (Print)9781118999196, 9780813812243
StatePublished - Dec 31 2013


  • Constant rate infusion (CRI)
  • Drug concentration
  • Intravenous infusions
  • Loading dose
  • Pharmacokinetics
  • Target-controlled infusion

ASJC Scopus subject areas

  • veterinary(all)


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