Pharmacokinetic-pharmacodynamic integration of orbifloxacin in Japanese quail (Coturnix japonica) following oral and intravenous administration

Michelle Hawkins, I. T. Taylor, Barbara A Byrne, R. D. Armstrong, Lisa A Tell

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The pharmacokinetics of single-dose administration of orbifloxacin were determined in Japanese quail (Coturnix japonica) at dosages of 5mg/kg intravenous (i.v. n=12) and 7.5mg/kg oral (p.o.; n=5), 10mg/kg p.o. (n=5), 15mg/kg p.o. (n=12) and 20mg/kg p.o. (n=5) via HPLC. Orbifloxacin minimal inhibitory concentrations (MICs) against 22 microbial isolates from various bird species were performed to calculate pharmacodynamic surrogate markers. The concentration-time data were analyzed using a naïve pooled data (NPD) approach and compartmental and noncompartmental methods. Steady-state volume of distribution (Vd ss) and total body clearance (Cl) after i.v. administration were estimated to be 1.27L/kg and 0.60L/h·kg, respectively. Following 15 and 20mg/kg p.o. dose, bioavailability was 102% and 117%, respectively. The harmonic mean of the corresponding terminal half-lives (T 1/2λ z) across all the dose groups was 1.71h. The C max/MIC 90 and AUC 0∞24/MIC 90 for the 15 and 20mg/kg p.o. doses were ≥5.22 and ≥8.98, and ≥25.80 and ≥39.37h, respectively. The results of this study suggest that 20mg/kg orbifloxacin p.o. would be a rational daily dose to treat susceptible infections in Japanese quail not intended for food consumption. For more sensitive bacterial organisms, 15mg/kg p.o. may also be effective.

Original languageEnglish (US)
Pages (from-to)350-358
Number of pages9
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume34
Issue number4
DOIs
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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