Abstract
The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography-mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 468-473 |
| Number of pages | 6 |
| Journal | Journal of Zoo and Wildlife Medicine |
| Volume | 47 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2016 |
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Keywords
- Analgesia
- avian
- fentanyl solution
- guineafowl
- Numida meleagris
- RecuvyraTM.
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
PHARMACOKINETIC EVALUATION of A LONG-ACTING FENTANYL SOLUTION after TRANSDERMAL ADMINISTRATION in HELMETED GUINEAFOWL (NUMIDA MELEAGRIS). / Waugh, Lynnette; Knych, Heather K; Cole, Gretchen; D'Agostino, Jennifer.
In: Journal of Zoo and Wildlife Medicine, Vol. 47, No. 2, 01.06.2016, p. 468-473.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - PHARMACOKINETIC EVALUATION of A LONG-ACTING FENTANYL SOLUTION after TRANSDERMAL ADMINISTRATION in HELMETED GUINEAFOWL (NUMIDA MELEAGRIS)
AU - Waugh, Lynnette
AU - Knych, Heather K
AU - Cole, Gretchen
AU - D'Agostino, Jennifer
PY - 2016/6/1
Y1 - 2016/6/1
N2 - The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography-mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.
AB - The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography-mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.
KW - Analgesia
KW - avian
KW - fentanyl solution
KW - guineafowl
KW - Numida meleagris
KW - RecuvyraTM.
UR - http://www.scopus.com/inward/record.url?scp=84982976096&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982976096&partnerID=8YFLogxK
U2 - 10.1638/2015-0220.1
DO - 10.1638/2015-0220.1
M3 - Article
C2 - 27468018
AN - SCOPUS:84982976096
VL - 47
SP - 468
EP - 473
JO - Journal of Zoo and Wildlife Medicine
JF - Journal of Zoo and Wildlife Medicine
SN - 1042-7260
IS - 2
ER -