Abstract
The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography-mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.
Original language | English (US) |
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Pages (from-to) | 468-473 |
Number of pages | 6 |
Journal | Journal of Zoo and Wildlife Medicine |
Volume | 47 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1 2016 |
Keywords
- Analgesia
- avian
- fentanyl solution
- guineafowl
- Numida meleagris
- RecuvyraTM.
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)