PHARMACOKINETIC EVALUATION of A LONG-ACTING FENTANYL SOLUTION after TRANSDERMAL ADMINISTRATION in HELMETED GUINEAFOWL (NUMIDA MELEAGRIS)

Lynnette Waugh; Heather K Knych; Gretchen Cole; Jennifer D'Agostino

doi:10.1638/2015-0220.1

PHARMACOKINETIC EVALUATION of A LONG-ACTING FENTANYL SOLUTION after TRANSDERMAL ADMINISTRATION in HELMETED GUINEAFOWL (NUMIDA MELEAGRIS)

Lynnette Waugh, Heather K Knych, Gretchen Cole, Jennifer D'Agostino

Equine Analytical Chemistry Program

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography-mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.

Original language	English (US)
Pages (from-to)	468-473
Number of pages	6
Journal	Journal of Zoo and Wildlife Medicine
Volume	47
Issue number	2
DOIs	https://doi.org/10.1638/2015-0220.1
State	Published - Jun 1 2016

Keywords

Analgesia
avian
fentanyl solution
guineafowl
Numida meleagris
RecuvyraTM.

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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title = "PHARMACOKINETIC EVALUATION of A LONG-ACTING FENTANYL SOLUTION after TRANSDERMAL ADMINISTRATION in HELMETED GUINEAFOWL (NUMIDA MELEAGRIS)",

abstract = "The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography-mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.",

keywords = "Analgesia, avian, fentanyl solution, guineafowl, Numida meleagris, RecuvyraTM.",

author = "Lynnette Waugh and Knych, {Heather K} and Gretchen Cole and Jennifer D'Agostino",

year = "2016",

month = jun,

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doi = "10.1638/2015-0220.1",

language = "English (US)",

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AU - Waugh, Lynnette

AU - Knych, Heather K

AU - Cole, Gretchen

AU - D'Agostino, Jennifer

PY - 2016/6/1

Y1 - 2016/6/1

N2 - The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography-mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.

AB - The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography-mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.

KW - Analgesia

KW - avian

KW - fentanyl solution

KW - guineafowl

KW - Numida meleagris

KW - RecuvyraTM.

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PHARMACOKINETIC EVALUATION of A LONG-ACTING FENTANYL SOLUTION after TRANSDERMAL ADMINISTRATION in HELMETED GUINEAFOWL (NUMIDA MELEAGRIS)

Abstract

Keywords

ASJC Scopus subject areas

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