PHARMACOKINETIC EVALUATION of A LONG-ACTING FENTANYL SOLUTION after TRANSDERMAL ADMINISTRATION in HELMETED GUINEAFOWL (NUMIDA MELEAGRIS)

Lynnette Waugh, Heather K Knych, Gretchen Cole, Jennifer D'Agostino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography-mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.

Original languageEnglish (US)
Pages (from-to)468-473
Number of pages6
JournalJournal of Zoo and Wildlife Medicine
Volume47
Issue number2
DOIs
StatePublished - Jun 1 2016

Fingerprint

guineafowl
fentanyl
Fentanyl
analgesics
liquid chromatography
pharmacokinetics
half life
Cutaneous Administration
adverse effects
mass spectrometry
Liquid Chromatography
dogs
Half-Life
Analgesics
dosage
Mass Spectrometry
Pharmacokinetics
Dogs
proteins
sampling

Keywords

  • Analgesia
  • avian
  • fentanyl solution
  • guineafowl
  • Numida meleagris
  • RecuvyraTM.

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

PHARMACOKINETIC EVALUATION of A LONG-ACTING FENTANYL SOLUTION after TRANSDERMAL ADMINISTRATION in HELMETED GUINEAFOWL (NUMIDA MELEAGRIS). / Waugh, Lynnette; Knych, Heather K; Cole, Gretchen; D'Agostino, Jennifer.

In: Journal of Zoo and Wildlife Medicine, Vol. 47, No. 2, 01.06.2016, p. 468-473.

Research output: Contribution to journalArticle

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