Phagocytic functions in thyroid cancer patients treated with radioiodine-131

S. Lechpammer, J. Lukac, G. J R Cook, Mirna Lechpammer, Z. Kusic

Research output: Contribution to journalArticle

Abstract

The study was designed to evaluate phagocytosis in 22 papillary thyroid cancer patients (mean age 42 years, 20 females) who were postoperatively treated with 131I for thyroid remnant ablation (mean dose 3.5 GBq). In these 22 patients (Group A), leukocyte count, proportion and absolute granulocyte and monocyte count, and their phagocytic functions were determined 4 weeks after the surgery but before 131I treatment. In 17 of these patients (group B), determinations were repeated 3 months after 131I ablation. Control measurements were performed in 74 healthy volunteers. In group A a decrease was recorded for absolute monocyte count (p=0.025), granulocyte ingestion (p=0.053) and microbidicity (p<0.001), and monocyte phagocytic activity (p=0.012) and ingestion (p=0.003) compared to controls. There were no differences between groups A and B. Results of the study showed immunologic changes to be present early in the disease process (group A). According, the impaired immunologic parameters observed in group B compared to controls could not be attributed to the effect of 131I.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalActa Clinica Croatica
Volume37
Issue number4
StatePublished - 1998
Externally publishedYes

Keywords

  • Iodine
  • Phagocytes
  • Physiology
  • Radioisotopes
  • Therapeutic use
  • Therapy
  • Thyroid neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Lechpammer, S., Lukac, J., Cook, G. J. R., Lechpammer, M., & Kusic, Z. (1998). Phagocytic functions in thyroid cancer patients treated with radioiodine-131. Acta Clinica Croatica, 37(4), 249-253.