Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves

Shuping Zhang, Renato L. Santos, Renee M Tsolis, Susanne Mirold, Wolf Dietrich Hardt, L. Garry Adams, Andreas J Baumler

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Epidemiological evidence shows that the sopE1 gene is associated with Salmonella Typhimurium phage types causing epidemics in cattle. In this study we demonstrate that horizontal transfer of the sopE1 gene by lysogenic conversion with the SopEΦ increased enteropathogenicity of S. Typhimurium in the bovine ligated ileal loop model. These data support the hypothesis that phage mediated horizontal transfer of the sopE1 gene contributes to the emergence of epidemic cattle-associated S. Typhimurium clones.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalFEMS Microbiology Letters
Volume217
Issue number2
DOIs
StatePublished - Dec 17 2002
Externally publishedYes

Fingerprint

Horizontal Gene Transfer
Salmonella enterica
Salmonella typhimurium
Bacteriophages
Salmonella Phages
Gene Conversion
Clone Cells
Genes
Serogroup

Keywords

  • Bacteriophage
  • Enteritis
  • Horizontal gene transfer
  • Salmonella
  • Type III secretion

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves. / Zhang, Shuping; Santos, Renato L.; Tsolis, Renee M; Mirold, Susanne; Hardt, Wolf Dietrich; Adams, L. Garry; Baumler, Andreas J.

In: FEMS Microbiology Letters, Vol. 217, No. 2, 17.12.2002, p. 243-247.

Research output: Contribution to journalArticle

Zhang, Shuping ; Santos, Renato L. ; Tsolis, Renee M ; Mirold, Susanne ; Hardt, Wolf Dietrich ; Adams, L. Garry ; Baumler, Andreas J. / Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves. In: FEMS Microbiology Letters. 2002 ; Vol. 217, No. 2. pp. 243-247.
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