pH-lactate dissociation in neonatal anoxia

Proton and 31P NMR spectroscopic studies in rat pups

K. Hida, N. Suzuki, Ingrid Kwee, T. Nakada

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The pH controlling capability of brain of 1-day-old rat pups was investigated using proton (1H) and phosphorus-31 (31P) nuclear magnetic resonance (NMR) in vivo spectroscopy. Despite significantly high levels of lactate accumulation, brain of 1-day-old pups showed remarkable capability of maintaining brain pH virtually unchanged throughout 22 min of anoxia. The study supports the concepts that lactic acidosis is one of the important factors determining the outcome of cerebral anoxia and that the significantly higher pH controlling capability of immature brain plays a key role in the higher resistance toward anoxia.

Original languageEnglish (US)
Pages (from-to)128-132
Number of pages5
JournalMagnetic Resonance in Medicine
Volume22
Issue number1
DOIs
StatePublished - 1991

Fingerprint

Protons
Lactic Acid
Magnetic Resonance Spectroscopy
Brain
Brain Hypoxia
Lactic Acidosis
Phosphorus
Spectrum Analysis
Hypoxia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

pH-lactate dissociation in neonatal anoxia : Proton and 31P NMR spectroscopic studies in rat pups. / Hida, K.; Suzuki, N.; Kwee, Ingrid; Nakada, T.

In: Magnetic Resonance in Medicine, Vol. 22, No. 1, 1991, p. 128-132.

Research output: Contribution to journalArticle

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