Abstract
The pH controlling capability of brain of 1-day-old rat pups was investigated using proton (1H) and phosphorus-31 (31P) nuclear magnetic resonance (NMR) in vivo spectroscopy. Despite significantly high levels of lactate accumulation, brain of 1-day-old pups showed remarkable capability of maintaining brain pH virtually unchanged throughout 22 min of anoxia. The study supports the concepts that lactic acidosis is one of the important factors determining the outcome of cerebral anoxia and that the significantly higher pH controlling capability of immature brain plays a key role in the higher resistance toward anoxia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 128-132 |
| Number of pages | 5 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1991 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
pH-lactate dissociation in neonatal anoxia : Proton and 31P NMR spectroscopic studies in rat pups. / Hida, K.; Suzuki, N.; Kwee, Ingrid; Nakada, T.
In: Magnetic Resonance in Medicine, Vol. 22, No. 1, 1991, p. 128-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - pH-lactate dissociation in neonatal anoxia
T2 - Proton and 31P NMR spectroscopic studies in rat pups
AU - Hida, K.
AU - Suzuki, N.
AU - Kwee, Ingrid
AU - Nakada, T.
PY - 1991
Y1 - 1991
N2 - The pH controlling capability of brain of 1-day-old rat pups was investigated using proton (1H) and phosphorus-31 (31P) nuclear magnetic resonance (NMR) in vivo spectroscopy. Despite significantly high levels of lactate accumulation, brain of 1-day-old pups showed remarkable capability of maintaining brain pH virtually unchanged throughout 22 min of anoxia. The study supports the concepts that lactic acidosis is one of the important factors determining the outcome of cerebral anoxia and that the significantly higher pH controlling capability of immature brain plays a key role in the higher resistance toward anoxia.
AB - The pH controlling capability of brain of 1-day-old rat pups was investigated using proton (1H) and phosphorus-31 (31P) nuclear magnetic resonance (NMR) in vivo spectroscopy. Despite significantly high levels of lactate accumulation, brain of 1-day-old pups showed remarkable capability of maintaining brain pH virtually unchanged throughout 22 min of anoxia. The study supports the concepts that lactic acidosis is one of the important factors determining the outcome of cerebral anoxia and that the significantly higher pH controlling capability of immature brain plays a key role in the higher resistance toward anoxia.
UR - http://www.scopus.com/inward/record.url?scp=0025786534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025786534&partnerID=8YFLogxK
U2 - 10.1002/mrm.1910220113
DO - 10.1002/mrm.1910220113
M3 - Article
VL - 22
SP - 128
EP - 132
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 1
ER -