pH-lactate dissociation during anoxic insult

Taurine effect

T. Nakada, K. Hida, Ingrid Kwee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Taurine, a sulfur amino acid abundant in brain of the fetus and early day neonate, has been postulated to play a major role in mediating the immature brain's unusually high buffering ability for lactic acidosis reported previously. In this study, we directly investigated this 'taurine effect' using a l0-day-old rat pup model and multinuclear (31P and 1H) nuclear magnetic resonance (NMR) in-vivo spectroscopy. Brain of taurine-supplemented pups exhibited significantly higher acid buffering ability against lactic acidosis than age-matched control pups. The study supports the hypothesis that high levels of free cytosolic taurine increase the brain's ability to buffer against lactic acidosis.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalNeuroReport
Volume2
Issue number6
StatePublished - 1991

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Taurine
Lactic Acidosis
Lactic Acid
Brain
Sulfur Amino Acids
Spectrum Analysis
Buffers
Fetus
Magnetic Resonance Spectroscopy
Acids

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

pH-lactate dissociation during anoxic insult : Taurine effect. / Nakada, T.; Hida, K.; Kwee, Ingrid.

In: NeuroReport, Vol. 2, No. 6, 1991, p. 325-328.

Research output: Contribution to journalArticle

Nakada, T, Hida, K & Kwee, I 1991, 'pH-lactate dissociation during anoxic insult: Taurine effect', NeuroReport, vol. 2, no. 6, pp. 325-328.
Nakada, T. ; Hida, K. ; Kwee, Ingrid. / pH-lactate dissociation during anoxic insult : Taurine effect. In: NeuroReport. 1991 ; Vol. 2, No. 6. pp. 325-328.
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