Abstract
Taurine, a sulfur amino acid abundant in brain of the fetus and early day neonate, has been postulated to play a major role in mediating the immature brain's unusually high buffering ability for lactic acidosis reported previously. In this study, we directly investigated this 'taurine effect' using a l0-day-old rat pup model and multinuclear (31P and 1H) nuclear magnetic resonance (NMR) in-vivo spectroscopy. Brain of taurine-supplemented pups exhibited significantly higher acid buffering ability against lactic acidosis than age-matched control pups. The study supports the hypothesis that high levels of free cytosolic taurine increase the brain's ability to buffer against lactic acidosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 325-328 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 2 |
| Issue number | 6 |
| State | Published - 1991 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
pH-lactate dissociation during anoxic insult : Taurine effect. / Nakada, T.; Hida, K.; Kwee, Ingrid.
In: NeuroReport, Vol. 2, No. 6, 1991, p. 325-328.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - pH-lactate dissociation during anoxic insult
T2 - Taurine effect
AU - Nakada, T.
AU - Hida, K.
AU - Kwee, Ingrid
PY - 1991
Y1 - 1991
N2 - Taurine, a sulfur amino acid abundant in brain of the fetus and early day neonate, has been postulated to play a major role in mediating the immature brain's unusually high buffering ability for lactic acidosis reported previously. In this study, we directly investigated this 'taurine effect' using a l0-day-old rat pup model and multinuclear (31P and 1H) nuclear magnetic resonance (NMR) in-vivo spectroscopy. Brain of taurine-supplemented pups exhibited significantly higher acid buffering ability against lactic acidosis than age-matched control pups. The study supports the hypothesis that high levels of free cytosolic taurine increase the brain's ability to buffer against lactic acidosis.
AB - Taurine, a sulfur amino acid abundant in brain of the fetus and early day neonate, has been postulated to play a major role in mediating the immature brain's unusually high buffering ability for lactic acidosis reported previously. In this study, we directly investigated this 'taurine effect' using a l0-day-old rat pup model and multinuclear (31P and 1H) nuclear magnetic resonance (NMR) in-vivo spectroscopy. Brain of taurine-supplemented pups exhibited significantly higher acid buffering ability against lactic acidosis than age-matched control pups. The study supports the hypothesis that high levels of free cytosolic taurine increase the brain's ability to buffer against lactic acidosis.
UR - http://www.scopus.com/inward/record.url?scp=0025896972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025896972&partnerID=8YFLogxK
M3 - Article
VL - 2
SP - 325
EP - 328
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 6
ER -