pH Dependent C6 and C8 13C chemical shift assignment in N-acetyl neuraminic acid

Jacquelyn Gervay-Hague; Gyula Batta

doi:10.1016/S0040-4039(00)76814-6

pH Dependent C6 and C8 ¹³C chemical shift assignment in N-acetyl neuraminic acid

Jacquelyn Gervay-Hague, Gyula Batta

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Heteronuclear correlation NMR spectroscopy was employed in the unambigous carbon chemical shift assignment of N-acetyl neuraminic acid at pH 1.0 and 7.0. Our results show that at pH 1.0 the C6 resonance is slightly downfield from that of C8 and at pH 7.0 the C6 and C8 chemical shifts are transposed. These experiments firmly establish carbon chemical shift assignments in N-acetyl neuraminic acid for the first time.

Original language	English (US)
Pages (from-to)	3009-3012
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	19
DOIs	https://doi.org/10.1016/S0040-4039(00)76814-6
State	Published - May 9 1994
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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title = "pH Dependent C6 and C8 13C chemical shift assignment in N-acetyl neuraminic acid",

abstract = "Heteronuclear correlation NMR spectroscopy was employed in the unambigous carbon chemical shift assignment of N-acetyl neuraminic acid at pH 1.0 and 7.0. Our results show that at pH 1.0 the C6 resonance is slightly downfield from that of C8 and at pH 7.0 the C6 and C8 chemical shifts are transposed. These experiments firmly establish carbon chemical shift assignments in N-acetyl neuraminic acid for the first time.",

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AU - Batta, Gyula

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N2 - Heteronuclear correlation NMR spectroscopy was employed in the unambigous carbon chemical shift assignment of N-acetyl neuraminic acid at pH 1.0 and 7.0. Our results show that at pH 1.0 the C6 resonance is slightly downfield from that of C8 and at pH 7.0 the C6 and C8 chemical shifts are transposed. These experiments firmly establish carbon chemical shift assignments in N-acetyl neuraminic acid for the first time.

AB - Heteronuclear correlation NMR spectroscopy was employed in the unambigous carbon chemical shift assignment of N-acetyl neuraminic acid at pH 1.0 and 7.0. Our results show that at pH 1.0 the C6 resonance is slightly downfield from that of C8 and at pH 7.0 the C6 and C8 chemical shifts are transposed. These experiments firmly establish carbon chemical shift assignments in N-acetyl neuraminic acid for the first time.

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