Abstract
Heteronuclear correlation NMR spectroscopy was employed in the unambigous carbon chemical shift assignment of N-acetyl neuraminic acid at pH 1.0 and 7.0. Our results show that at pH 1.0 the C6 resonance is slightly downfield from that of C8 and at pH 7.0 the C6 and C8 chemical shifts are transposed. These experiments firmly establish carbon chemical shift assignments in N-acetyl neuraminic acid for the first time.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3009-3012 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 35 |
| Issue number | 19 |
| DOIs | |
| State | Published - May 9 1994 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Gervay-Hague, J., & Batta, G. (1994). pH Dependent C6 and C8 13C chemical shift assignment in N-acetyl neuraminic acid. Tetrahedron Letters, 35(19), 3009-3012. https://doi.org/10.1016/S0040-4039(00)76814-6