PET/MRI radiotracer beyond 18F-FDG

Miguel Hernandez Pampaloni, Lorenzo Nardo

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The recent development and introduction of new hybrid imaging devices combining positron emission tomography (PET) technology with magnetic resonance imaging (MRI) opens up new perspectives in clinical molecular imaging. Combining MRI and fluorine-18 choline PET would theoretically produce valuable clinical data in a single imaging session, which can be used for staging, prognosis, and assessment of treatment response. Fluorine-18-sodium fluoride (18F-NaF) is a highly sensitive PET tracer used as a marker of osteoblastic abnormalities. PET imaging with 68 Ga-DOTATATE or DOTATOC has demonstrated promising results for locating metastatic lesions, occasionally with superior sensitivity than whole-body MRI. l-DOPA PET adds data regarding l-DOPA metabolism, which may increase the specificity and sensibility of the study itself. Fluoromisonidazole is known to be not only a useful tracer for determining hypoxic cells but also an efficient hypoxic radiosensitizer.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalPET Clinics
Volume9
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Positron-Emission Tomography
magnetic resonance
positrons
tomography
Magnetic Resonance Imaging
Fluorine
tracers
fluorine
Multimodal Imaging
sodium fluorides
choline
Sodium Fluoride
Molecular Imaging
prognosis
sensitivity
abnormalities
metabolism
Choline
markers

Keywords

  • Imaging
  • MRI
  • PET
  • Radiotracers

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Medicine(all)

Cite this

PET/MRI radiotracer beyond 18F-FDG. / Pampaloni, Miguel Hernandez; Nardo, Lorenzo.

In: PET Clinics, Vol. 9, No. 3, 01.01.2014, p. 345-349.

Research output: Contribution to journalReview article

Pampaloni, Miguel Hernandez ; Nardo, Lorenzo. / PET/MRI radiotracer beyond 18F-FDG. In: PET Clinics. 2014 ; Vol. 9, No. 3. pp. 345-349.
@article{0bf63a243954485781ec48b19a38b3b8,
title = "PET/MRI radiotracer beyond 18F-FDG",
abstract = "The recent development and introduction of new hybrid imaging devices combining positron emission tomography (PET) technology with magnetic resonance imaging (MRI) opens up new perspectives in clinical molecular imaging. Combining MRI and fluorine-18 choline PET would theoretically produce valuable clinical data in a single imaging session, which can be used for staging, prognosis, and assessment of treatment response. Fluorine-18-sodium fluoride (18F-NaF) is a highly sensitive PET tracer used as a marker of osteoblastic abnormalities. PET imaging with 68 Ga-DOTATATE or DOTATOC has demonstrated promising results for locating metastatic lesions, occasionally with superior sensitivity than whole-body MRI. l-DOPA PET adds data regarding l-DOPA metabolism, which may increase the specificity and sensibility of the study itself. Fluoromisonidazole is known to be not only a useful tracer for determining hypoxic cells but also an efficient hypoxic radiosensitizer.",
keywords = "Imaging, MRI, PET, Radiotracers",
author = "Pampaloni, {Miguel Hernandez} and Lorenzo Nardo",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.cpet.2014.03.010",
language = "English (US)",
volume = "9",
pages = "345--349",
journal = "PET Clinics",
issn = "1556-8598",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - PET/MRI radiotracer beyond 18F-FDG

AU - Pampaloni, Miguel Hernandez

AU - Nardo, Lorenzo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The recent development and introduction of new hybrid imaging devices combining positron emission tomography (PET) technology with magnetic resonance imaging (MRI) opens up new perspectives in clinical molecular imaging. Combining MRI and fluorine-18 choline PET would theoretically produce valuable clinical data in a single imaging session, which can be used for staging, prognosis, and assessment of treatment response. Fluorine-18-sodium fluoride (18F-NaF) is a highly sensitive PET tracer used as a marker of osteoblastic abnormalities. PET imaging with 68 Ga-DOTATATE or DOTATOC has demonstrated promising results for locating metastatic lesions, occasionally with superior sensitivity than whole-body MRI. l-DOPA PET adds data regarding l-DOPA metabolism, which may increase the specificity and sensibility of the study itself. Fluoromisonidazole is known to be not only a useful tracer for determining hypoxic cells but also an efficient hypoxic radiosensitizer.

AB - The recent development and introduction of new hybrid imaging devices combining positron emission tomography (PET) technology with magnetic resonance imaging (MRI) opens up new perspectives in clinical molecular imaging. Combining MRI and fluorine-18 choline PET would theoretically produce valuable clinical data in a single imaging session, which can be used for staging, prognosis, and assessment of treatment response. Fluorine-18-sodium fluoride (18F-NaF) is a highly sensitive PET tracer used as a marker of osteoblastic abnormalities. PET imaging with 68 Ga-DOTATATE or DOTATOC has demonstrated promising results for locating metastatic lesions, occasionally with superior sensitivity than whole-body MRI. l-DOPA PET adds data regarding l-DOPA metabolism, which may increase the specificity and sensibility of the study itself. Fluoromisonidazole is known to be not only a useful tracer for determining hypoxic cells but also an efficient hypoxic radiosensitizer.

KW - Imaging

KW - MRI

KW - PET

KW - Radiotracers

UR - http://www.scopus.com/inward/record.url?scp=84903594449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903594449&partnerID=8YFLogxK

U2 - 10.1016/j.cpet.2014.03.010

DO - 10.1016/j.cpet.2014.03.010

M3 - Review article

VL - 9

SP - 345

EP - 349

JO - PET Clinics

JF - PET Clinics

SN - 1556-8598

IS - 3

ER -