PET/MRI radiotracer beyond 18F-FDG

Miguel Hernandez Pampaloni, Lorenzo Nardo

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

The recent development and introduction of new hybrid imaging devices combining positron emission tomography (PET) technology with magnetic resonance imaging (MRI) opens up new perspectives in clinical molecular imaging. Combining MRI and fluorine-18 choline PET would theoretically produce valuable clinical data in a single imaging session, which can be used for staging, prognosis, and assessment of treatment response. Fluorine-18-sodium fluoride (18F-NaF) is a highly sensitive PET tracer used as a marker of osteoblastic abnormalities. PET imaging with 68 Ga-DOTATATE or DOTATOC has demonstrated promising results for locating metastatic lesions, occasionally with superior sensitivity than whole-body MRI. l-DOPA PET adds data regarding l-DOPA metabolism, which may increase the specificity and sensibility of the study itself. Fluoromisonidazole is known to be not only a useful tracer for determining hypoxic cells but also an efficient hypoxic radiosensitizer.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalPET Clinics
Volume9
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Imaging
  • MRI
  • PET
  • Radiotracers

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Medicine(all)

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