Abstract
A growing body of evidence suggests that rhesus macaques may be a good model of human brain aging. We used positron emission tomography (PET) and 18F-fluorodeoxyglucose (FDG) to measure regional cerebral metabolic rates for glucose (rCMRglc) in young and aged rhesus macaques to determine if age-related decreases, such as those reported in humans, also occur in macaques. Whereas the aged animals had lower metabolic rates in every brain region studied, the largest differences were in left temporal cortex. The largest differences were also observed in left temporal cortex when relative rCMRglc values were used. Both rCMRglc and relative rCMRglc were marked by substantial individual variation within the aged group. This variation may parallel the variation observed in behavioral studies. Future studies that include both PET and behavioral measures should help determine if there is a relationship between age-related changes in rCMRglc and behavior.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 825-832 |
| Number of pages | 8 |
| Journal | Neurobiology of Aging |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1995 |
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Keywords
- Aging
- Glucose metabolism
- Monkey
- PET
- Rhesus macaques
- Temporal cortex
ASJC Scopus subject areas
- Aging
- Developmental Biology
- Geriatrics and Gerontology
- Clinical Neurology
- Neuroscience(all)
- Biological Psychiatry
- Developmental Neuroscience
- Neurology
- Psychology(all)
Cite this
PET studies of cerebral glucose metabolism in conscious rhesus macaques. / Eberling, Jamie L.; Roberts, Jeffrey A; De Manincor, Darlene J.; Brennan, Kathleen M.; Hanrahan, Stephen M.; Vanbrocklin, Henry F.; Roos, Mark S.; Jagust, William J.
In: Neurobiology of Aging, Vol. 16, No. 5, 1995, p. 825-832.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - PET studies of cerebral glucose metabolism in conscious rhesus macaques
AU - Eberling, Jamie L.
AU - Roberts, Jeffrey A
AU - De Manincor, Darlene J.
AU - Brennan, Kathleen M.
AU - Hanrahan, Stephen M.
AU - Vanbrocklin, Henry F.
AU - Roos, Mark S.
AU - Jagust, William J.
PY - 1995
Y1 - 1995
N2 - A growing body of evidence suggests that rhesus macaques may be a good model of human brain aging. We used positron emission tomography (PET) and 18F-fluorodeoxyglucose (FDG) to measure regional cerebral metabolic rates for glucose (rCMRglc) in young and aged rhesus macaques to determine if age-related decreases, such as those reported in humans, also occur in macaques. Whereas the aged animals had lower metabolic rates in every brain region studied, the largest differences were in left temporal cortex. The largest differences were also observed in left temporal cortex when relative rCMRglc values were used. Both rCMRglc and relative rCMRglc were marked by substantial individual variation within the aged group. This variation may parallel the variation observed in behavioral studies. Future studies that include both PET and behavioral measures should help determine if there is a relationship between age-related changes in rCMRglc and behavior.
AB - A growing body of evidence suggests that rhesus macaques may be a good model of human brain aging. We used positron emission tomography (PET) and 18F-fluorodeoxyglucose (FDG) to measure regional cerebral metabolic rates for glucose (rCMRglc) in young and aged rhesus macaques to determine if age-related decreases, such as those reported in humans, also occur in macaques. Whereas the aged animals had lower metabolic rates in every brain region studied, the largest differences were in left temporal cortex. The largest differences were also observed in left temporal cortex when relative rCMRglc values were used. Both rCMRglc and relative rCMRglc were marked by substantial individual variation within the aged group. This variation may parallel the variation observed in behavioral studies. Future studies that include both PET and behavioral measures should help determine if there is a relationship between age-related changes in rCMRglc and behavior.
KW - Aging
KW - Glucose metabolism
KW - Monkey
KW - PET
KW - Rhesus macaques
KW - Temporal cortex
UR - http://www.scopus.com/inward/record.url?scp=0028874566&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028874566&partnerID=8YFLogxK
U2 - 10.1016/0197-4580(95)00085-S
DO - 10.1016/0197-4580(95)00085-S
M3 - Article
VL - 16
SP - 825
EP - 832
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 5
ER -