PET studies of cerebral glucose metabolism in conscious rhesus macaques

Jamie L. Eberling; Jeffrey A Roberts; Darlene J. De Manincor; Kathleen M. Brennan; Stephen M. Hanrahan; Henry F. Vanbrocklin; Mark S. Roos; William J. Jagust

doi:10.1016/0197-4580(95)00085-S

PET studies of cerebral glucose metabolism in conscious rhesus macaques

Jamie L. Eberling, Jeffrey A Roberts, Darlene J. De Manincor, Kathleen M. Brennan, Stephen M. Hanrahan, Henry F. Vanbrocklin, Mark S. Roos, William J. Jagust

Medicine and Epidemiology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A growing body of evidence suggests that rhesus macaques may be a good model of human brain aging. We used positron emission tomography (PET) and ¹⁸F-fluorodeoxyglucose (FDG) to measure regional cerebral metabolic rates for glucose (rCMRglc) in young and aged rhesus macaques to determine if age-related decreases, such as those reported in humans, also occur in macaques. Whereas the aged animals had lower metabolic rates in every brain region studied, the largest differences were in left temporal cortex. The largest differences were also observed in left temporal cortex when relative rCMRglc values were used. Both rCMRglc and relative rCMRglc were marked by substantial individual variation within the aged group. This variation may parallel the variation observed in behavioral studies. Future studies that include both PET and behavioral measures should help determine if there is a relationship between age-related changes in rCMRglc and behavior.

Original language	English (US)
Pages (from-to)	825-832
Number of pages	8
Journal	Neurobiology of Aging
Volume	16
Issue number	5
DOIs	https://doi.org/10.1016/0197-4580(95)00085-S
State	Published - 1995

Keywords

Aging
Glucose metabolism
Monkey
PET
Rhesus macaques
Temporal cortex

ASJC Scopus subject areas

Aging
Developmental Biology
Geriatrics and Gerontology
Clinical Neurology
Neuroscience(all)
Biological Psychiatry
Developmental Neuroscience
Neurology
Psychology(all)

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title = "PET studies of cerebral glucose metabolism in conscious rhesus macaques",

abstract = "A growing body of evidence suggests that rhesus macaques may be a good model of human brain aging. We used positron emission tomography (PET) and 18F-fluorodeoxyglucose (FDG) to measure regional cerebral metabolic rates for glucose (rCMRglc) in young and aged rhesus macaques to determine if age-related decreases, such as those reported in humans, also occur in macaques. Whereas the aged animals had lower metabolic rates in every brain region studied, the largest differences were in left temporal cortex. The largest differences were also observed in left temporal cortex when relative rCMRglc values were used. Both rCMRglc and relative rCMRglc were marked by substantial individual variation within the aged group. This variation may parallel the variation observed in behavioral studies. Future studies that include both PET and behavioral measures should help determine if there is a relationship between age-related changes in rCMRglc and behavior.",

keywords = "Aging, Glucose metabolism, Monkey, PET, Rhesus macaques, Temporal cortex",

author = "Eberling, {Jamie L.} and Roberts, {Jeffrey A} and {De Manincor}, {Darlene J.} and Brennan, {Kathleen M.} and Hanrahan, {Stephen M.} and Vanbrocklin, {Henry F.} and Roos, {Mark S.} and Jagust, {William J.}",

year = "1995",

doi = "10.1016/0197-4580(95)00085-S",

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AU - Eberling, Jamie L.

AU - Roberts, Jeffrey A

AU - De Manincor, Darlene J.

AU - Brennan, Kathleen M.

AU - Hanrahan, Stephen M.

AU - Vanbrocklin, Henry F.

AU - Roos, Mark S.

AU - Jagust, William J.

PY - 1995

Y1 - 1995

N2 - A growing body of evidence suggests that rhesus macaques may be a good model of human brain aging. We used positron emission tomography (PET) and 18F-fluorodeoxyglucose (FDG) to measure regional cerebral metabolic rates for glucose (rCMRglc) in young and aged rhesus macaques to determine if age-related decreases, such as those reported in humans, also occur in macaques. Whereas the aged animals had lower metabolic rates in every brain region studied, the largest differences were in left temporal cortex. The largest differences were also observed in left temporal cortex when relative rCMRglc values were used. Both rCMRglc and relative rCMRglc were marked by substantial individual variation within the aged group. This variation may parallel the variation observed in behavioral studies. Future studies that include both PET and behavioral measures should help determine if there is a relationship between age-related changes in rCMRglc and behavior.

AB - A growing body of evidence suggests that rhesus macaques may be a good model of human brain aging. We used positron emission tomography (PET) and 18F-fluorodeoxyglucose (FDG) to measure regional cerebral metabolic rates for glucose (rCMRglc) in young and aged rhesus macaques to determine if age-related decreases, such as those reported in humans, also occur in macaques. Whereas the aged animals had lower metabolic rates in every brain region studied, the largest differences were in left temporal cortex. The largest differences were also observed in left temporal cortex when relative rCMRglc values were used. Both rCMRglc and relative rCMRglc were marked by substantial individual variation within the aged group. This variation may parallel the variation observed in behavioral studies. Future studies that include both PET and behavioral measures should help determine if there is a relationship between age-related changes in rCMRglc and behavior.

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KW - Glucose metabolism

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KW - Rhesus macaques

KW - Temporal cortex

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