PET-enabled Dual-energy CT: A Proof-of-Concept Simulation Study

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Standard dual-energy CT uses two different x-ray energies to obtain energy-dependent tissue attenuation information to allow quantitative material decomposition. Combined use of dual-energy CT and PET may provide a more comprehensive characterization of disease states in cancer and many other diseases. However, integration of dual-energy CT with PET is not trivial, either requiring costly hardware upgrade or increasing radiation dose. This paper proposes a novel dual-energy CT imaging method that is enabled by the already-available PET data on PET/CT. Instead of using a second x-ray CT scan with a different energy, this method exploits time-of-flight PET image reconstruction to obtain a 511 keV gamma-ray attenuation image from PET emission data and combines the high-energy gamma-ray CT image with the low-energy x-ray CT of PET/CT to provide a pair of dual-energy CT images. We conducted a computer simulation to test the concept for material decomposition using air, soft tissue, fat and calcium. The simulations results indicate that this PET-enabled dual-energy CT method is promising for quantitative material decomposition, though future work is needed for noise supression. The proposed method can be readily implemented on time-of-flight PET/CT scanners to enable simultaneous PET and dual-energy CT for multiparametric imaging.

Original languageEnglish (US)
Title of host publication2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538684948
DOIs
StatePublished - Nov 2018
Event2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Sydney, Australia
Duration: Nov 10 2018Nov 17 2018

Publication series

Name2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings

Conference

Conference2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018
CountryAustralia
CitySydney
Period11/10/1811/17/18

Keywords

  • dual-energy CT
  • image reconstruction
  • multi-material decomposition
  • Time-of-flight PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Nuclear and High Energy Physics

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