PET characteristics of a dedicated breast PET/CT scanner prototype

Yibao Wu, Spencer L. Bowen, Kai Yang, Nathan Packard, Lin Fu, George Burkett, Jinyi Qi, John M Boone, Simon R Cherry, Ramsey D Badawi

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A dedicated breast PET/CT system has been constructed at our institution, with the goal of having increased spatial resolution and sensitivity compared to whole-body systems. The purpose of this work is to describe the design and the performance characteristics of the PET component of this device. Average spatial resolution of a line source in warm background using maximum a posteriori (MAP) reconstruction was 2.5 mm, while the average spatial resolution of a phantom containing point sources using filtered back projection (FBP) was 3.27 mm. A sensitivity profile was computed with a point source translated across the axial field of view (FOV) and a peak sensitivity of 1.64% was measured at the center of the FOV. The average energy resolution determined on a per-crystal basis was 25%. The characteristic dead time for the front-end electronics and data acquisition (DAQ) was determined to be 145 ns and 3.6 νs, respectively. With no activity outside the FOV, a peak noise-equivalent count rate of 18.6 kcps was achieved at 318 νCi (11.766 MBq) in a cylindrical phantom of diameter 75 mm. After the effects of exposing PET detectors to x-ray flux were evaluated and ameliorated, a combined PET/CT scan was performed. The percentage standard deviations of uniformity along axial and transaxial directions were 3.7% and 2.8%, respectively. The impact of the increased reconstructed spatial resolution compared to typical whole-body PET scanners is currently being assessed in a clinical trial.

Original languageEnglish (US)
Pages (from-to)4273-4287
Number of pages15
JournalPhysics in Medicine and Biology
Volume54
Issue number13
DOIs
StatePublished - 2009

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Noise
Breast
X-Rays
Clinical Trials
Equipment and Supplies
Positron Emission Tomography Computed Tomography
Direction compound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

PET characteristics of a dedicated breast PET/CT scanner prototype. / Wu, Yibao; Bowen, Spencer L.; Yang, Kai; Packard, Nathan; Fu, Lin; Burkett, George; Qi, Jinyi; Boone, John M; Cherry, Simon R; Badawi, Ramsey D.

In: Physics in Medicine and Biology, Vol. 54, No. 13, 2009, p. 4273-4287.

Research output: Contribution to journalArticle

Wu, Yibao ; Bowen, Spencer L. ; Yang, Kai ; Packard, Nathan ; Fu, Lin ; Burkett, George ; Qi, Jinyi ; Boone, John M ; Cherry, Simon R ; Badawi, Ramsey D. / PET characteristics of a dedicated breast PET/CT scanner prototype. In: Physics in Medicine and Biology. 2009 ; Vol. 54, No. 13. pp. 4273-4287.
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