Perturbed zinc homeostasis in rural 3-5-y-old malawian children is associated with abnormalities in intestinal permeability attributed to tropical enteropathy

Micah J. Manary, Steven A. Abrams, Ian J. Griffin, Megan M. Quimper, Robert J. Shulman, Maria G. Hamzo, Zhensheng Chen, Kenneth Maleta, Mark J. Manary

Research output: Contribution to journalArticle

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Abstract

Tropical enteropathy and zinc deficiency are major public health problems worldwide. Tropical enteropathy is characterized by reduced mannitol absorption with normal or increased lactulose absorption when a dual sugar absorption test is administered, the results of which are reported as the lactulose:mannitol ratio (L:M). Zinc homeostasis is quantified with a dual stable isotope test. This study tested the hypothesis that endogenous fecal zinc (EFZ) was correlated with the L:M. A dual sugar absorption test and dual stable isotope test were performed on 25 asymptomatic Malawian children aged 3-5 y at risk for tropical enteropathy and zinc deficiency. EFZ and net zinc retention were estimated and correlated with the L:M. Twenty-two children (88%) had an abnormal L:M (L:M >0.10), and the L:M was 0.24 ± 0.10 (mean ± SD). EFZ was 1.68 ± 1.06 mg/d, a quantity greater than is seen in healthy populations from the developed world. EFZ was positively correlated with the L:M (r = 0.62, p < 0.001). Net zinc retention (0.67 ± 1.6 mg/d) was negatively correlated with the L:M (r =-0.47, p = 0.02). This suggests that perturbed zinc homeostasis is associated with subclinical enteropathy in these children.

Original languageEnglish (US)
Pages (from-to)671-675
Number of pages5
JournalPediatric Research
Volume67
Issue number6
DOIs
StatePublished - Jun 2010

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Lactulose
Zinc
Permeability
Homeostasis
Mannitol
Isotopes
Public Health

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Perturbed zinc homeostasis in rural 3-5-y-old malawian children is associated with abnormalities in intestinal permeability attributed to tropical enteropathy. / Manary, Micah J.; Abrams, Steven A.; Griffin, Ian J.; Quimper, Megan M.; Shulman, Robert J.; Hamzo, Maria G.; Chen, Zhensheng; Maleta, Kenneth; Manary, Mark J.

In: Pediatric Research, Vol. 67, No. 6, 06.2010, p. 671-675.

Research output: Contribution to journalArticle

Manary, MJ, Abrams, SA, Griffin, IJ, Quimper, MM, Shulman, RJ, Hamzo, MG, Chen, Z, Maleta, K & Manary, MJ 2010, 'Perturbed zinc homeostasis in rural 3-5-y-old malawian children is associated with abnormalities in intestinal permeability attributed to tropical enteropathy', Pediatric Research, vol. 67, no. 6, pp. 671-675. https://doi.org/10.1203/PDR.0b013e3181da44dc
Manary, Micah J. ; Abrams, Steven A. ; Griffin, Ian J. ; Quimper, Megan M. ; Shulman, Robert J. ; Hamzo, Maria G. ; Chen, Zhensheng ; Maleta, Kenneth ; Manary, Mark J. / Perturbed zinc homeostasis in rural 3-5-y-old malawian children is associated with abnormalities in intestinal permeability attributed to tropical enteropathy. In: Pediatric Research. 2010 ; Vol. 67, No. 6. pp. 671-675.
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abstract = "Tropical enteropathy and zinc deficiency are major public health problems worldwide. Tropical enteropathy is characterized by reduced mannitol absorption with normal or increased lactulose absorption when a dual sugar absorption test is administered, the results of which are reported as the lactulose:mannitol ratio (L:M). Zinc homeostasis is quantified with a dual stable isotope test. This study tested the hypothesis that endogenous fecal zinc (EFZ) was correlated with the L:M. A dual sugar absorption test and dual stable isotope test were performed on 25 asymptomatic Malawian children aged 3-5 y at risk for tropical enteropathy and zinc deficiency. EFZ and net zinc retention were estimated and correlated with the L:M. Twenty-two children (88{\%}) had an abnormal L:M (L:M >0.10), and the L:M was 0.24 ± 0.10 (mean ± SD). EFZ was 1.68 ± 1.06 mg/d, a quantity greater than is seen in healthy populations from the developed world. EFZ was positively correlated with the L:M (r = 0.62, p < 0.001). Net zinc retention (0.67 ± 1.6 mg/d) was negatively correlated with the L:M (r =-0.47, p = 0.02). This suggests that perturbed zinc homeostasis is associated with subclinical enteropathy in these children.",
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