Perturbations in the model of estrogen receptor regulation of gene expression

J. Gorski, John Furlow, F. E. Murdoch, M. Fritsch, K. Kaneko, C. Ying, J. R. Malayer

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Estrogen receptors are key elements in the mechanisms of action of estrogenic hormones. Models of how estrogens and their receptors interact and subsequently modify gene expression should be reevaluated to explain new data currently available. The following review discusses nuclear localization, DNA binding, and protein structural changes of the estrogen receptor induced by estrogen binding. We also discuss how these phenomena relate to the induction of changes in gene expression.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalBiology of Reproduction
Volume48
Issue number1
DOIs
StatePublished - Jan 5 1993
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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    Gorski, J., Furlow, J., Murdoch, F. E., Fritsch, M., Kaneko, K., Ying, C., & Malayer, J. R. (1993). Perturbations in the model of estrogen receptor regulation of gene expression. Biology of Reproduction, 48(1), 8-14. https://doi.org/10.1095/biolreprod48.1.8