Abstract
Enhanced metabolism of glucose via the polyol pathway may play an important role in the pathogenesis of diabetic retinopathy, neuropathy, and nephropathy. Aldose reductase catalyzes the NADPH-dependent conversion of glucose to sorbitol, the first step in the polyol pathway. Interruption of the polyol pathway by inhibition of aldose reductase holds considerable promise as a therapeutic measure to prevent or delay the onset and severity of these late complications of diabetes. Dramatic advances in our understanding of the molecular biology, enzymology, and three-dimensional structure of aldose reductase have occurred in recent years, providing new and challenging insights into the enzyme's catalytic mechanism. Recent developments in structure determination of aldose reductase and the implications for evaluation and development of aldose reductase inhibitors are summarized.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 955-959 |
| Number of pages | 5 |
| Journal | Diabetes |
| Volume | 43 |
| Issue number | 8 |
| State | Published - 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
Cite this
Perspectives in diabetes : Aldose reductase catalysis and crystallography: Insights from recent advances in enzyme structure and function. / Petrash, J. Mark; Tarle, Ivan; Wilson, David K.; Quiocho, Florante A.
In: Diabetes, Vol. 43, No. 8, 1994, p. 955-959.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Perspectives in diabetes
T2 - Aldose reductase catalysis and crystallography: Insights from recent advances in enzyme structure and function
AU - Petrash, J. Mark
AU - Tarle, Ivan
AU - Wilson, David K.
AU - Quiocho, Florante A.
PY - 1994
Y1 - 1994
N2 - Enhanced metabolism of glucose via the polyol pathway may play an important role in the pathogenesis of diabetic retinopathy, neuropathy, and nephropathy. Aldose reductase catalyzes the NADPH-dependent conversion of glucose to sorbitol, the first step in the polyol pathway. Interruption of the polyol pathway by inhibition of aldose reductase holds considerable promise as a therapeutic measure to prevent or delay the onset and severity of these late complications of diabetes. Dramatic advances in our understanding of the molecular biology, enzymology, and three-dimensional structure of aldose reductase have occurred in recent years, providing new and challenging insights into the enzyme's catalytic mechanism. Recent developments in structure determination of aldose reductase and the implications for evaluation and development of aldose reductase inhibitors are summarized.
AB - Enhanced metabolism of glucose via the polyol pathway may play an important role in the pathogenesis of diabetic retinopathy, neuropathy, and nephropathy. Aldose reductase catalyzes the NADPH-dependent conversion of glucose to sorbitol, the first step in the polyol pathway. Interruption of the polyol pathway by inhibition of aldose reductase holds considerable promise as a therapeutic measure to prevent or delay the onset and severity of these late complications of diabetes. Dramatic advances in our understanding of the molecular biology, enzymology, and three-dimensional structure of aldose reductase have occurred in recent years, providing new and challenging insights into the enzyme's catalytic mechanism. Recent developments in structure determination of aldose reductase and the implications for evaluation and development of aldose reductase inhibitors are summarized.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028037576&partnerID=8YFLogxK
M3 - Article
VL - 43
SP - 955
EP - 959
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 8
ER -