TY - JOUR
T1 - Perspective
T2 - Fundamental and clinical concepts on stem cell homing and engraftment: A journey to niches and beyond
AU - Quesenberry, Peter J.
AU - Colvin, Gerald
AU - Abedi, Mehrdad
PY - 2005/1
Y1 - 2005/1
N2 - In many ways, the homing of hematopoietic stem cells to bone marrow and other tissues defines these cells and their immediate and long-term fates Once homed, an inevitable series of proliferative and differentiative events presumptively follows. These comments, of course, hold for both homing to marrow, or alternatively, to other nonmarrow tissues. In this review, we will specifically focus on homing and engraftment to bone marrow because this is the best-studied and clinically applicable system.
AB - In many ways, the homing of hematopoietic stem cells to bone marrow and other tissues defines these cells and their immediate and long-term fates Once homed, an inevitable series of proliferative and differentiative events presumptively follows. These comments, of course, hold for both homing to marrow, or alternatively, to other nonmarrow tissues. In this review, we will specifically focus on homing and engraftment to bone marrow because this is the best-studied and clinically applicable system.
UR - http://www.scopus.com/inward/record.url?scp=12344324650&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12344324650&partnerID=8YFLogxK
U2 - 10.1016/j.exphem.2004.10.012
DO - 10.1016/j.exphem.2004.10.012
M3 - Article
C2 - 15661393
AN - SCOPUS:12344324650
VL - 33
SP - 9
EP - 19
JO - Experimental Hematology
JF - Experimental Hematology
SN - 0301-472X
IS - 1
ER -