Perspective: Fundamental and clinical concepts on stem cell homing and engraftment: A journey to niches and beyond

Peter J. Quesenberry, Gerald Colvin, Mehrdad Abedi

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

In many ways, the homing of hematopoietic stem cells to bone marrow and other tissues defines these cells and their immediate and long-term fates Once homed, an inevitable series of proliferative and differentiative events presumptively follows. These comments, of course, hold for both homing to marrow, or alternatively, to other nonmarrow tissues. In this review, we will specifically focus on homing and engraftment to bone marrow because this is the best-studied and clinically applicable system.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalExperimental Hematology
Volume33
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

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