Abstract
At the start of the 21st century, the human genome project provided the scientific community with an enormous array of information as genetic blueprints. A landmark period, yet its potential contribution to medicine at the time was limited and unknown. However, with new technological advances, the benefits of identifying genomic profiles became apparent. This article reviews the historical accomplishments made by the human genome project, future applications of genomic expression profiles with the use of microarray gene chip technology, and the pharmacogenomic translational application of these models to dermatology. A new scientific movement in dermatology has begun with intentions of discovering individual genomic profiles responsible for dermatologic disease and drug metabolism, so that medical management can be personalized towards the genome rather than the disease. This review shows how pharmacogenomics has taken the lead in forming a basic framework of revealing specific drug metabolic pathways in the skin that can consequently be altered to maximize and minimize therapeutic efficacy and side effects, respectively. Dermatology as a model field in medicine has started to take advantage of these discoveries upon which deciphering genetic profiles can be used to enhance medical treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 161-167 |
| Number of pages | 7 |
| Journal | Journal of Dermatological Treatment |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2012 |
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Keywords
- Anti-aging
- Microarray
- Pharmacogenomics
- Skin care
ASJC Scopus subject areas
- Dermatology
Cite this
Personalizing dermatology : The future of genomic expression profiling to individualize dermatologic therapy. / Rizzo, Amilcar Ezequiel; Maibach, Howard I.
In: Journal of Dermatological Treatment, Vol. 23, No. 3, 06.2012, p. 161-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Personalizing dermatology
T2 - The future of genomic expression profiling to individualize dermatologic therapy
AU - Rizzo, Amilcar Ezequiel
AU - Maibach, Howard I.
PY - 2012/6
Y1 - 2012/6
N2 - At the start of the 21st century, the human genome project provided the scientific community with an enormous array of information as genetic blueprints. A landmark period, yet its potential contribution to medicine at the time was limited and unknown. However, with new technological advances, the benefits of identifying genomic profiles became apparent. This article reviews the historical accomplishments made by the human genome project, future applications of genomic expression profiles with the use of microarray gene chip technology, and the pharmacogenomic translational application of these models to dermatology. A new scientific movement in dermatology has begun with intentions of discovering individual genomic profiles responsible for dermatologic disease and drug metabolism, so that medical management can be personalized towards the genome rather than the disease. This review shows how pharmacogenomics has taken the lead in forming a basic framework of revealing specific drug metabolic pathways in the skin that can consequently be altered to maximize and minimize therapeutic efficacy and side effects, respectively. Dermatology as a model field in medicine has started to take advantage of these discoveries upon which deciphering genetic profiles can be used to enhance medical treatment.
AB - At the start of the 21st century, the human genome project provided the scientific community with an enormous array of information as genetic blueprints. A landmark period, yet its potential contribution to medicine at the time was limited and unknown. However, with new technological advances, the benefits of identifying genomic profiles became apparent. This article reviews the historical accomplishments made by the human genome project, future applications of genomic expression profiles with the use of microarray gene chip technology, and the pharmacogenomic translational application of these models to dermatology. A new scientific movement in dermatology has begun with intentions of discovering individual genomic profiles responsible for dermatologic disease and drug metabolism, so that medical management can be personalized towards the genome rather than the disease. This review shows how pharmacogenomics has taken the lead in forming a basic framework of revealing specific drug metabolic pathways in the skin that can consequently be altered to maximize and minimize therapeutic efficacy and side effects, respectively. Dermatology as a model field in medicine has started to take advantage of these discoveries upon which deciphering genetic profiles can be used to enhance medical treatment.
KW - Anti-aging
KW - Microarray
KW - Pharmacogenomics
KW - Skin care
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U2 - 10.3109/09546634.2010.535806
DO - 10.3109/09546634.2010.535806
M3 - Article
C2 - 21254882
AN - SCOPUS:84861041361
VL - 23
SP - 161
EP - 167
JO - Journal of Dermatological Treatment
JF - Journal of Dermatological Treatment
SN - 0954-6634
IS - 3
ER -