Personalizing cardiac regenerative therapy: At the heart of Pim1 kinase

Kaitlen Samse, Nirmala Hariharan, Mark A. Sussman

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

During cardiac aging, DNA damage and environmental stressors contribute to telomeric shortening and human cardiac progenitor cells acquire a senescent phenotype that leads to decreased stem cell function. Reversion of this phenotype through genetic modification is essential to advance regenerative therapy. Studies in the cardiac specific overexpression and subcellular targeting of Pim1 kinase demonstrate its influence on regeneration, proliferation, survival, metabolism and senescence. The cardioprotective effects of Pim1 modification can be picked apart and enhanced by targeting the kinase to distinct subcellular compartments, allowing for selection of specific phenotypic traits after molecular modification. In this perspective, we examine the therapeutic implications of Pim1 to encourage the personalization of cardiac regenerative therapy.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
JournalPharmacological Research
Volume103
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Aging
  • Apoptosis
  • Heart failure
  • Human cardiac progenitor cell
  • Pim1
  • Senescence

ASJC Scopus subject areas

  • Pharmacology

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