Abstract
Objective:We studied the associations between personality traits and the risk of coronary heart disease (CHD) or stroke in women with diabetes.Methods:From the Women's Health Initiative, 15,029 women aged 50 to 79 years at enrollment and with self-reported treated diabetes at baseline or follow-up, were followed for a mean of 10 years. Personality traits measured from validated scales included hostility, optimism, ambivalence over emotional expressiveness, and negative emotional expressiveness. Multivariable Cox proportional-hazards regression models were used to examine associations between personality traits and the risk of adjudicated CHD (nonfatal myocardial infarction and CHD death) or stroke outcomes. Progressively adjusted regression approach was used in the multivariable models to adjust for demographics, depression, anthropometric variables, and lifestyle factors.Results:A total of 1,118 incident CHD and 710 incident stroke cases were observed. Women in the highest quartile of hostility had 22% (hazard ratio [HR] 1.22, 95% confidence interval [CI] 1.01-1.48) increased risk for CHD compared with women in the lowest quartile of hostility. P values for trend were greater than 0.05. Stratified analysis by prevalent or incident diabetes showed that the highest quartile of hostility had 34% increased risk for CHD (HR 1.34, 95% CI 1.03-1.74) among women with incident diabetes. Other personality traits were not significantly associated with stroke or CHD.Conclusions:Hostility was associated with incidence of CHD among postmenopausal women with diabetes, especially among incident diabetes. These results provide a basis for targeted prevention programs for women with a high level of hostility and diabetes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1117-1124 |
| Number of pages | 8 |
| Journal | Menopause |
| Volume | 26 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2019 |
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Keywords
- Coronary heart disease
- Epidemiology
- Personality traits
- Stroke
- Type 2 diabetes
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Personality traits and the risk of coronary heart disease or stroke in women with diabetes-an epidemiological study based on the Women's Health Initiative. / Jonasson, Junmei Miao; Hendryx, Michael; Manson, Jo Ann E.; Dinh, Paul; Garcia, Lorena; Liu, Simin; Luo, Juhua.
In: Menopause, Vol. 26, No. 10, 01.10.2019, p. 1117-1124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Personality traits and the risk of coronary heart disease or stroke in women with diabetes-an epidemiological study based on the Women's Health Initiative
AU - Jonasson, Junmei Miao
AU - Hendryx, Michael
AU - Manson, Jo Ann E.
AU - Dinh, Paul
AU - Garcia, Lorena
AU - Liu, Simin
AU - Luo, Juhua
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Objective:We studied the associations between personality traits and the risk of coronary heart disease (CHD) or stroke in women with diabetes.Methods:From the Women's Health Initiative, 15,029 women aged 50 to 79 years at enrollment and with self-reported treated diabetes at baseline or follow-up, were followed for a mean of 10 years. Personality traits measured from validated scales included hostility, optimism, ambivalence over emotional expressiveness, and negative emotional expressiveness. Multivariable Cox proportional-hazards regression models were used to examine associations between personality traits and the risk of adjudicated CHD (nonfatal myocardial infarction and CHD death) or stroke outcomes. Progressively adjusted regression approach was used in the multivariable models to adjust for demographics, depression, anthropometric variables, and lifestyle factors.Results:A total of 1,118 incident CHD and 710 incident stroke cases were observed. Women in the highest quartile of hostility had 22% (hazard ratio [HR] 1.22, 95% confidence interval [CI] 1.01-1.48) increased risk for CHD compared with women in the lowest quartile of hostility. P values for trend were greater than 0.05. Stratified analysis by prevalent or incident diabetes showed that the highest quartile of hostility had 34% increased risk for CHD (HR 1.34, 95% CI 1.03-1.74) among women with incident diabetes. Other personality traits were not significantly associated with stroke or CHD.Conclusions:Hostility was associated with incidence of CHD among postmenopausal women with diabetes, especially among incident diabetes. These results provide a basis for targeted prevention programs for women with a high level of hostility and diabetes.
AB - Objective:We studied the associations between personality traits and the risk of coronary heart disease (CHD) or stroke in women with diabetes.Methods:From the Women's Health Initiative, 15,029 women aged 50 to 79 years at enrollment and with self-reported treated diabetes at baseline or follow-up, were followed for a mean of 10 years. Personality traits measured from validated scales included hostility, optimism, ambivalence over emotional expressiveness, and negative emotional expressiveness. Multivariable Cox proportional-hazards regression models were used to examine associations between personality traits and the risk of adjudicated CHD (nonfatal myocardial infarction and CHD death) or stroke outcomes. Progressively adjusted regression approach was used in the multivariable models to adjust for demographics, depression, anthropometric variables, and lifestyle factors.Results:A total of 1,118 incident CHD and 710 incident stroke cases were observed. Women in the highest quartile of hostility had 22% (hazard ratio [HR] 1.22, 95% confidence interval [CI] 1.01-1.48) increased risk for CHD compared with women in the lowest quartile of hostility. P values for trend were greater than 0.05. Stratified analysis by prevalent or incident diabetes showed that the highest quartile of hostility had 34% increased risk for CHD (HR 1.34, 95% CI 1.03-1.74) among women with incident diabetes. Other personality traits were not significantly associated with stroke or CHD.Conclusions:Hostility was associated with incidence of CHD among postmenopausal women with diabetes, especially among incident diabetes. These results provide a basis for targeted prevention programs for women with a high level of hostility and diabetes.
KW - Coronary heart disease
KW - Epidemiology
KW - Personality traits
KW - Stroke
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85072790601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072790601&partnerID=8YFLogxK
U2 - 10.1097/GME.0000000000001382
DO - 10.1097/GME.0000000000001382
M3 - Article
C2 - 31479031
AN - SCOPUS:85072790601
VL - 26
SP - 1117
EP - 1124
JO - Menopause
JF - Menopause
SN - 1072-3714
IS - 10
ER -