Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease

Ilan Dar-Nimrod, Benjamin P. Chapman, Peter Franks, John A Robbins, Anton Porsteinsson, Mark Mapstone, Paul R. Duberstein

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Objectives: We tested the hypothesis that neuroticism moderates the association between APOE (apolipoprotein E) genotype and two major outcomes, cognitive function and Alzheimer disease. We also explored whether other personality dimensions (extraversion, openness to experience, agreeableness, and conscientiousness) moderate the associations of APOE with these outcomes. Design: Primary analyses of existing randomized clinical trial data. Sample: Six-hundred two older adults (mean age of 78 years at baseline). Measurements: APOE genotype, the NEO-Five Factor Inventory, the Alzheimer's Disease Assessment Scale-Cognitive: measured every 6 months for 6.5 years) and relevant covariates. Results: Fully adjusted multivariate analyses showed that the association between the presence of APOE [Latin Small Letter Open E]-4 allele(s) and both outcomes was evident among individuals with high levels of neuroticism and extraversion but not among persons with low levels of these traits. Conclusions: Phenotypic personality dimensions, primarily neuroticism and extraversion, moderate the relationship between APOE [Latin Small Letter Open E]-4 genotype and cognitive outcomes among older adults. Future research is needed to elucidate the physiological processes involved in these particular phenotype-genotype interactions.

Original languageEnglish (US)
Pages (from-to)1026-1035
Number of pages10
JournalAmerican Journal of Geriatric Psychiatry
Volume20
Issue number12
DOIs
StatePublished - Dec 2012

Keywords

  • Alzheimer disease
  • APOE genotype
  • cognitive function
  • G × E interaction
  • personality

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

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