Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma

Ralph J. Delfino, Norbert Staimer, Dan Gillen, Thomas Tjoa, Constantinos Sioutas, Kochy Fung, Steven George, Michael T. Kleinman

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Background: Research has shown associations between pediatric asthma outcomes and airborne particulate matter (PM). The importance of particle components remains to be determined. Methods: We followed a panel of 45 school children with persistent asthma living in Southern California. Subjects were monitored over 10 days with offline fractional exhaled nitric oxide (FENO), a biomarker of airway inflammation. Personal active sampler exposures included continuous particulate matter < 2.5 μm in aerodynamic diameter (PM2.5), 24-hr PM2.5 elemental and organic carbon (EC, OC), and 24-hr nitrogen dioxide. Ambient exposures included PM2.5, PM2.5 EC and OC, and NO2. Data were analyzed with mixed models controlling for personal temperature, humidity and 10-day period. Result: The strongest positive associations were between FENO and 2-day average pollutant concentrations. Per interquartile range pollutant increase, these were: for 24 μg/m3 personal PM2.5, 1.1 ppb FENO [95% confidence interval (CI), 0.1-1.9]; for 0.6 μg/m3 personal EC, 0.7 ppb FENO (95% CI, 0.3-1.1); for 17 ppb personal NO2, 1.6 ppb FENO (95% CI, 0.4-2.8). Larger associations were found for ambient EC and smaller associations for ambient NO2. Ambient PM2.5 and personal and ambient OC were significant only in subjects taking inhaled corticosteroids (ICS) alone. Subjects taking both ICS and antileukotrienes showed no significant associations. Distributed lag models showed personal PM2.5 in the preceding 5 hr was associated with FENO. In two-pollutant models, the most robust associations were for personal and ambient EC and NO2, and for personal but not ambient PM2.5. Conclusion: PM associations with airway inflammation in asthmatics may be missed using ambient particle mass, which may not sufficiently represent causal pollutant components from fossil fuel combustion.

Original languageEnglish (US)
Pages (from-to)1736-1743
Number of pages8
JournalEnvironmental Health Perspectives
Volume114
Issue number11
DOIs
StatePublished - Nov 1 2006

Fingerprint

Air Pollution
Nitric Oxide
Asthma
Particulate Matter
Confidence Intervals
Adrenal Cortex Hormones
Fossil Fuels
Inflammation
Nitrogen Dioxide
Humidity
Carbon
Biomarkers
Pediatrics
Temperature
Research

Keywords

  • Asthma
  • Epidemiology
  • Exhaled nitric oxide
  • Longitudinal data analysis
  • Nitrogen dioxide
  • Ozone
  • Panel study
  • Particulate air pollution

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Delfino, R. J., Staimer, N., Gillen, D., Tjoa, T., Sioutas, C., Fung, K., ... Kleinman, M. T. (2006). Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma. Environmental Health Perspectives, 114(11), 1736-1743. https://doi.org/10.1289/ehp.9141

Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma. / Delfino, Ralph J.; Staimer, Norbert; Gillen, Dan; Tjoa, Thomas; Sioutas, Constantinos; Fung, Kochy; George, Steven; Kleinman, Michael T.

In: Environmental Health Perspectives, Vol. 114, No. 11, 01.11.2006, p. 1736-1743.

Research output: Contribution to journalArticle

Delfino, RJ, Staimer, N, Gillen, D, Tjoa, T, Sioutas, C, Fung, K, George, S & Kleinman, MT 2006, 'Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma', Environmental Health Perspectives, vol. 114, no. 11, pp. 1736-1743. https://doi.org/10.1289/ehp.9141
Delfino, Ralph J. ; Staimer, Norbert ; Gillen, Dan ; Tjoa, Thomas ; Sioutas, Constantinos ; Fung, Kochy ; George, Steven ; Kleinman, Michael T. / Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma. In: Environmental Health Perspectives. 2006 ; Vol. 114, No. 11. pp. 1736-1743.
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abstract = "Background: Research has shown associations between pediatric asthma outcomes and airborne particulate matter (PM). The importance of particle components remains to be determined. Methods: We followed a panel of 45 school children with persistent asthma living in Southern California. Subjects were monitored over 10 days with offline fractional exhaled nitric oxide (FENO), a biomarker of airway inflammation. Personal active sampler exposures included continuous particulate matter < 2.5 μm in aerodynamic diameter (PM2.5), 24-hr PM2.5 elemental and organic carbon (EC, OC), and 24-hr nitrogen dioxide. Ambient exposures included PM2.5, PM2.5 EC and OC, and NO2. Data were analyzed with mixed models controlling for personal temperature, humidity and 10-day period. Result: The strongest positive associations were between FENO and 2-day average pollutant concentrations. Per interquartile range pollutant increase, these were: for 24 μg/m3 personal PM2.5, 1.1 ppb FENO [95{\%} confidence interval (CI), 0.1-1.9]; for 0.6 μg/m3 personal EC, 0.7 ppb FENO (95{\%} CI, 0.3-1.1); for 17 ppb personal NO2, 1.6 ppb FENO (95{\%} CI, 0.4-2.8). Larger associations were found for ambient EC and smaller associations for ambient NO2. Ambient PM2.5 and personal and ambient OC were significant only in subjects taking inhaled corticosteroids (ICS) alone. Subjects taking both ICS and antileukotrienes showed no significant associations. Distributed lag models showed personal PM2.5 in the preceding 5 hr was associated with FENO. In two-pollutant models, the most robust associations were for personal and ambient EC and NO2, and for personal but not ambient PM2.5. Conclusion: PM associations with airway inflammation in asthmatics may be missed using ambient particle mass, which may not sufficiently represent causal pollutant components from fossil fuel combustion.",
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AU - Sioutas, Constantinos

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AB - Background: Research has shown associations between pediatric asthma outcomes and airborne particulate matter (PM). The importance of particle components remains to be determined. Methods: We followed a panel of 45 school children with persistent asthma living in Southern California. Subjects were monitored over 10 days with offline fractional exhaled nitric oxide (FENO), a biomarker of airway inflammation. Personal active sampler exposures included continuous particulate matter < 2.5 μm in aerodynamic diameter (PM2.5), 24-hr PM2.5 elemental and organic carbon (EC, OC), and 24-hr nitrogen dioxide. Ambient exposures included PM2.5, PM2.5 EC and OC, and NO2. Data were analyzed with mixed models controlling for personal temperature, humidity and 10-day period. Result: The strongest positive associations were between FENO and 2-day average pollutant concentrations. Per interquartile range pollutant increase, these were: for 24 μg/m3 personal PM2.5, 1.1 ppb FENO [95% confidence interval (CI), 0.1-1.9]; for 0.6 μg/m3 personal EC, 0.7 ppb FENO (95% CI, 0.3-1.1); for 17 ppb personal NO2, 1.6 ppb FENO (95% CI, 0.4-2.8). Larger associations were found for ambient EC and smaller associations for ambient NO2. Ambient PM2.5 and personal and ambient OC were significant only in subjects taking inhaled corticosteroids (ICS) alone. Subjects taking both ICS and antileukotrienes showed no significant associations. Distributed lag models showed personal PM2.5 in the preceding 5 hr was associated with FENO. In two-pollutant models, the most robust associations were for personal and ambient EC and NO2, and for personal but not ambient PM2.5. Conclusion: PM associations with airway inflammation in asthmatics may be missed using ambient particle mass, which may not sufficiently represent causal pollutant components from fossil fuel combustion.

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KW - Epidemiology

KW - Exhaled nitric oxide

KW - Longitudinal data analysis

KW - Nitrogen dioxide

KW - Ozone

KW - Panel study

KW - Particulate air pollution

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