Abstract
The effects of excitotoxic lesions of the nucleus basalis magnocellularis on cortical cholinergic activity and passive avoidance performance were examined in rats at 6, 14, 84 and 180 days after lesioning. Lesioned rats showed significant impairment of passive avoidance retention at every time point tested, with no evidence of behavioral recovery compared to unoperated and sham-lesioned (i.e., vehicle-injected) control rats. Cortical choline acetyltransferase (CAT) activity was reduced relative to controls at all time points examined, with the greatest reduction (i.e., 28%) occuring at approximately 14 days after lesioning. The levels of CAT activity at 180 postlesioning remained reduced compared to control animal levels, but less so than at 14 days after lesioning, indicating partial recovery. No changes in cholinergic muscarinic binding were observed at any time following lesioning. The results indicate that the behavioral and neurochemical effects of NbM lesions persist for at least 6 months following lesioning, but that partial, gradual recovery of cholinergic activity occurs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 581-586 |
| Number of pages | 6 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1988 |
| Externally published | Yes |
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Keywords
- Basal forebrain
- Choline acetyltransferase
- Cholinergic system
- Excitotoxic lesions
- Muscarinic cholinergic receptors
- Passive avoidance
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Persisting behavioral and neurochemical deficits in rats following lesions of the basal forebrain. / Berman, Robert F; Crosland, R. D.; Jenden, D. J.; Altman, H. J.
In: Pharmacology, Biochemistry and Behavior, Vol. 29, No. 3, 1988, p. 581-586.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Persisting behavioral and neurochemical deficits in rats following lesions of the basal forebrain
AU - Berman, Robert F
AU - Crosland, R. D.
AU - Jenden, D. J.
AU - Altman, H. J.
PY - 1988
Y1 - 1988
N2 - The effects of excitotoxic lesions of the nucleus basalis magnocellularis on cortical cholinergic activity and passive avoidance performance were examined in rats at 6, 14, 84 and 180 days after lesioning. Lesioned rats showed significant impairment of passive avoidance retention at every time point tested, with no evidence of behavioral recovery compared to unoperated and sham-lesioned (i.e., vehicle-injected) control rats. Cortical choline acetyltransferase (CAT) activity was reduced relative to controls at all time points examined, with the greatest reduction (i.e., 28%) occuring at approximately 14 days after lesioning. The levels of CAT activity at 180 postlesioning remained reduced compared to control animal levels, but less so than at 14 days after lesioning, indicating partial recovery. No changes in cholinergic muscarinic binding were observed at any time following lesioning. The results indicate that the behavioral and neurochemical effects of NbM lesions persist for at least 6 months following lesioning, but that partial, gradual recovery of cholinergic activity occurs.
AB - The effects of excitotoxic lesions of the nucleus basalis magnocellularis on cortical cholinergic activity and passive avoidance performance were examined in rats at 6, 14, 84 and 180 days after lesioning. Lesioned rats showed significant impairment of passive avoidance retention at every time point tested, with no evidence of behavioral recovery compared to unoperated and sham-lesioned (i.e., vehicle-injected) control rats. Cortical choline acetyltransferase (CAT) activity was reduced relative to controls at all time points examined, with the greatest reduction (i.e., 28%) occuring at approximately 14 days after lesioning. The levels of CAT activity at 180 postlesioning remained reduced compared to control animal levels, but less so than at 14 days after lesioning, indicating partial recovery. No changes in cholinergic muscarinic binding were observed at any time following lesioning. The results indicate that the behavioral and neurochemical effects of NbM lesions persist for at least 6 months following lesioning, but that partial, gradual recovery of cholinergic activity occurs.
KW - Basal forebrain
KW - Choline acetyltransferase
KW - Cholinergic system
KW - Excitotoxic lesions
KW - Muscarinic cholinergic receptors
KW - Passive avoidance
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UR - http://www.scopus.com/inward/citedby.url?scp=0024158306&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(88)90023-8
DO - 10.1016/0091-3057(88)90023-8
M3 - Article
C2 - 3362952
AN - SCOPUS:0024158306
VL - 29
SP - 581
EP - 586
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 3
ER -