TY - JOUR
T1 - Persistent vitellogenin-like protein and binding of DDT in the serum of insecticide-resistant mosquitofish (Gambusia Affinis)
AU - Denison, Michael S.
AU - Chambers, Janice E.
AU - Yarbrough, James D.
PY - 1981
Y1 - 1981
N2 - 1. During the reproductive season the serum of most oviparous teleosts contains an electrophoretically-identifiable protein, vitellogenin. 2. However, serum from insecticide-resistant mosquitofish contain a vitellogenin-like protein (VLP) year round. 3. It is suggested that estrogenic and/or proestrogenic xenobiotics from the environment of the fish induces the formation of this protein during the non-reproductive season. 4. In vitro incubation of [p,p′-3H]DDT with reproductive or non-reproductive resistant and susceptible fish serum, led to its association with three separate proteins (VLP, a low molecular weight lipoprotein and albumin). 5. Xenobiotics thus may induce the formation of protein (VLP), in non-reproductive resistant fish, which can bind and transport insecticides.
AB - 1. During the reproductive season the serum of most oviparous teleosts contains an electrophoretically-identifiable protein, vitellogenin. 2. However, serum from insecticide-resistant mosquitofish contain a vitellogenin-like protein (VLP) year round. 3. It is suggested that estrogenic and/or proestrogenic xenobiotics from the environment of the fish induces the formation of this protein during the non-reproductive season. 4. In vitro incubation of [p,p′-3H]DDT with reproductive or non-reproductive resistant and susceptible fish serum, led to its association with three separate proteins (VLP, a low molecular weight lipoprotein and albumin). 5. Xenobiotics thus may induce the formation of protein (VLP), in non-reproductive resistant fish, which can bind and transport insecticides.
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U2 - 10.1016/0306-4492(81)90108-8
DO - 10.1016/0306-4492(81)90108-8
M3 - Article
C2 - 6113078
AN - SCOPUS:0019418006
VL - 69
SP - 109
EP - 112
JO - Comparative biochemistry and physiology. C: Comparative pharmacology
JF - Comparative biochemistry and physiology. C: Comparative pharmacology
SN - 0742-8413
IS - 1
ER -