Persistent vitellogenin-like protein and binding of DDT in the serum of insecticide-resistant mosquitofish (Gambusia Affinis)

Michael S. Denison, Janice E. Chambers, James D. Yarbrough

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

1. During the reproductive season the serum of most oviparous teleosts contains an electrophoretically-identifiable protein, vitellogenin. 2. However, serum from insecticide-resistant mosquitofish contain a vitellogenin-like protein (VLP) year round. 3. It is suggested that estrogenic and/or proestrogenic xenobiotics from the environment of the fish induces the formation of this protein during the non-reproductive season. 4. In vitro incubation of [p,p′-3H]DDT with reproductive or non-reproductive resistant and susceptible fish serum, led to its association with three separate proteins (VLP, a low molecular weight lipoprotein and albumin). 5. Xenobiotics thus may induce the formation of protein (VLP), in non-reproductive resistant fish, which can bind and transport insecticides.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume69
Issue number1
DOIs
StatePublished - 1981
Externally publishedYes

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Cyprinodontiformes
Vitellogenins
DDT
Insecticides
Protein Binding
Serum
Proteins
Fishes
Xenobiotics
Oviparity
vinyl polysiloxane
Lipoproteins
Albumins
Molecular Weight

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Persistent vitellogenin-like protein and binding of DDT in the serum of insecticide-resistant mosquitofish (Gambusia Affinis). / Denison, Michael S.; Chambers, Janice E.; Yarbrough, James D.

In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 69, No. 1, 1981, p. 109-112.

Research output: Contribution to journalArticle

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