Persistent pulmonary hypertension of the newborn: Role of nitric oxide and endothelin in pathophysiology and treatment

Robin H Steinhorn, S. L. Millard, F. C. Morin

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Persistent pulmonary hypertension of the newborn (PPHN) results in significant morbidity and mortality in otherwise normal term infants. Safe, effective therapies for PPHN will only be possible when they can be directed toward the specific defects producing this condition. In this review, the authors discuss three different categories of mediators that may play a role in the normal transition at birth and in the pathophysiology seen in PPHN: (1) lipid mediators, (2) the peptide endothelin, and (3) the oxidant radical, nitric oxide. The potential of using the last mediator, nitric oxide, as a treatment for PPHN is under intensive investigation and is discussed in the final section.

Original languageEnglish (US)
Pages (from-to)405-428
Number of pages24
JournalClinics in Perinatology
Volume22
Issue number2
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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