Persistent pulmonary hypertension of the newborn: Role of nitric oxide and endothelin in pathophysiology and treatment

Robin H Steinhorn, S. L. Millard, F. C. Morin

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Persistent pulmonary hypertension of the newborn (PPHN) results in significant morbidity and mortality in otherwise normal term infants. Safe, effective therapies for PPHN will only be possible when they can be directed toward the specific defects producing this condition. In this review, the authors discuss three different categories of mediators that may play a role in the normal transition at birth and in the pathophysiology seen in PPHN: (1) lipid mediators, (2) the peptide endothelin, and (3) the oxidant radical, nitric oxide. The potential of using the last mediator, nitric oxide, as a treatment for PPHN is under intensive investigation and is discussed in the final section.

Original languageEnglish (US)
Pages (from-to)405-428
Number of pages24
JournalClinics in Perinatology
Volume22
Issue number2
StatePublished - 1995
Externally publishedYes

Fingerprint

Persistent Fetal Circulation Syndrome
Endothelins
Nitric Oxide
Endothelin-3
Therapeutics
Oxidants
Parturition
Morbidity
Lipids
Peptides
Mortality

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Persistent pulmonary hypertension of the newborn : Role of nitric oxide and endothelin in pathophysiology and treatment. / Steinhorn, Robin H; Millard, S. L.; Morin, F. C.

In: Clinics in Perinatology, Vol. 22, No. 2, 1995, p. 405-428.

Research output: Contribution to journalArticle

Steinhorn, Robin H ; Millard, S. L. ; Morin, F. C. / Persistent pulmonary hypertension of the newborn : Role of nitric oxide and endothelin in pathophysiology and treatment. In: Clinics in Perinatology. 1995 ; Vol. 22, No. 2. pp. 405-428.
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