Persistent mammary hyperplasia in FVB/N mice

Ana I. Nieto, G. Shyamala, Jose J. Galvez, Gudmundur Thordarson, Lalage M. Wakefield, Robert Cardiff

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The inbred FVB/N mouse strain is widely used for creating transgenic mice. Over the past decade, persistent mammary hyperplasia has been detected in many multiparous FVB/N female mice sent to the University of California, Davis (UCD) Mutant Mouse Pathology Laboratory (MMPL) by a number of different laboratories. However, the experimental details concerning most specimens were not always available. To confirm these empiric findings, experiments were carried out to evaluate the mammary glands of FVB/N mice under controlled conditions. Persistent mammary hyperplasia that related to parity was found. Weeks after their first to fourth pregnancy, 10 FVB/N female mice from the Lawrence Berkeley National Laboratory (LBNL) colony were studied and the mammary glands were evaluated. The percentage of fat pad filled was estimated, using image analysis. Serum samples and the pituitary gland from other FVB/N mice from the LBNL were assayed for prolactin concentration. Multiparous FVB/N females consistently had persistent mammary hyperplasia. Four of seven females in the LBNL colony had hyperplasia after three pregnancies. A few foci of squamous nodules and sporadic carcinomas also were observed. Thus, some FVB/N females may have persistent mammary hyperplasia after three pregnancies without detectable pituitary abnormalities. Mammary carcinomas also may develop sporadically. These background phenotypes must be considered when interpreting the effect of genetic manipulation in FVB/N mice.

Original languageEnglish (US)
Pages (from-to)433-438
Number of pages6
JournalComparative Medicine
Volume53
Issue number4
StatePublished - Aug 1 2003

Fingerprint

hyperplasia
breasts
Hyperplasia
Breast
mice
Human Mammary Glands
Pregnancy
pregnancy
mammary glands
Pathology
Prolactin
Image analysis
Pituitary Gland
Fats
Parity
pituitary gland
Transgenic Mice
parity (reproduction)
prolactin
Adipose Tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Nieto, A. I., Shyamala, G., Galvez, J. J., Thordarson, G., Wakefield, L. M., & Cardiff, R. (2003). Persistent mammary hyperplasia in FVB/N mice. Comparative Medicine, 53(4), 433-438.

Persistent mammary hyperplasia in FVB/N mice. / Nieto, Ana I.; Shyamala, G.; Galvez, Jose J.; Thordarson, Gudmundur; Wakefield, Lalage M.; Cardiff, Robert.

In: Comparative Medicine, Vol. 53, No. 4, 01.08.2003, p. 433-438.

Research output: Contribution to journalArticle

Nieto, AI, Shyamala, G, Galvez, JJ, Thordarson, G, Wakefield, LM & Cardiff, R 2003, 'Persistent mammary hyperplasia in FVB/N mice', Comparative Medicine, vol. 53, no. 4, pp. 433-438.
Nieto AI, Shyamala G, Galvez JJ, Thordarson G, Wakefield LM, Cardiff R. Persistent mammary hyperplasia in FVB/N mice. Comparative Medicine. 2003 Aug 1;53(4):433-438.
Nieto, Ana I. ; Shyamala, G. ; Galvez, Jose J. ; Thordarson, Gudmundur ; Wakefield, Lalage M. ; Cardiff, Robert. / Persistent mammary hyperplasia in FVB/N mice. In: Comparative Medicine. 2003 ; Vol. 53, No. 4. pp. 433-438.
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