Persistent in vitro interaction of virulent and attenuated canine distemper virus with bovine cells

A. E. Metzler, Robert Higgins, S. Krakowka, A. Koestner

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Bovine macrophage and non-macrophage cultures were infected with either virulent or attenuated canine distemper virus (CDV). Macrophages were resistant to virulent CDV; however, they supported growth of the attenuated virus. Nonmacrophage cultures supported growth of both virus variants in a persistent, non-lytic manner. Major differences between these two systems of in vitro viral persistence were seen in the host cell spectrum of progeny virus and the outcome of cocultivation experiments with Vero cells. Results obtained indicate that in vivo virulence of CDV is not linked to maturation in a macrophage, but rather, propagation in a given cell culture system results in selective growth of virulent or attenuated viral mutants. It is further concluded that in vivo virulence and in vitro growth potential of CDV are disparate properties of the virion.

Original languageEnglish (US)
Pages (from-to)329-339
Number of pages11
JournalArchives of Virology
Volume66
Issue number4
DOIs
StatePublished - Dec 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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